GENOTOXIC EFFECT OF PARACETAMOL CONTAINING TABLETS IN CULTURED HUMAN LYMPHOCYTES
DOI:
https://doi.org/10.7439/ijbr.v1i2.54Keywords:
Human Immunodeficiency Virus (HIV), Rapid Tests, Stability beyond storage temperature.Abstract
Lymphocytes are the key cells in body defense system against foreign pathogens. Any agent which causes reduction in their number and viability can seriously impair the body defense system. Paracetamol or acetaminophen is a widely used over the counter drug for many common ailments. Acute or overdoses of commonly used tablets containing paracetamol causes undesired effects in human body often leading to death. Although there are extensive reports about the toxicity of paracetamol in association with liver failure and kidney functions, little is known about its effect in cultured lymphocytes and the effect on human DNA. This study focuses on the genotoxic effects of commonly used tablets containing Paracetamol in cultured human lymphocytes using routine cytotoxic assays viability and counting of cultured lymphocytes.
Downloads
Downloads
Published
Issue
Section
License
Copyright (c) 2010 International Journal of Biomedical Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- An author must submit Copyright form After acceptance of the article.