NEUROMUSCULAR BLOCKING EFFECT OF CONTINUOUS INFUSION OF VECURONIUM BROMIDE AND INTERMITTENT ADMINISTRATION OF PANCURONIUM BROMIDE AND VECURONIUM BROMIDE- A CLINICAL COMPARATIVE STUDY
DOI:
https://doi.org/10.7439/ijbr.v1i1.248Keywords:
Neuromuscular blockade, Vecuronium, Pancuronium, Bromide, Haemodynamic stability, Bolus dose, Maintenance dose, Recovery timeAbstract
Aim and Objectives: To compare the continuous infusion of vecuronium bromide with intermittent incremental administration of vecuronium bromide and pancuronium bromide in terms of the quality of neuromuscular blockade, haemodynamic stability, recovery profiles and complications.
Method: Total 60 patients were enrolled and randomly divided into three equal groups. Group A received injection pancuronium bromide 0.075mg/kg as bolus dose followed by 0.015mg/kg of maintenance dose. Group B received injection vecuronium bromide 0.075mg/kg as bolus dose followed by 0.015 mg/kg of maintenance dose. Group C patients received injection vecuronium bromide 0.075mg/kg as bolus dose followed by an infusion of vecuronium delivering at the rate of 0.075 mg/kg/hr.
Results: Mean time of onset for neuromuscular blockage was 5.05±3.4, 3.15±2.6 and 3±1.6 min in group A, B and C respectively. The clinical duration of bolus dose was 51.75min in group A and 27.65min in group B. Duration of action of maintenance dose was 30±18.4min and 17.8±6.7min in group A and B respectively. The recovery time was 36.3±4.73min in group A, 16.3±3.24min in group B and 16.95±3.13 min in group C. The mean level of block was 88.9±14.2 in group A, 88.05±9.8 in group B and 91.3±7.6 in group C. Group A showed significant rise in pulse rate at 15 min (97.5±16.5bpm) and 30 min (96.55±9.5bpm) while group B and C showed significant decreased in pulse rate at 180 min of intraoperative period from baseline value.
Conclusion: Infusion of vecuronium is a safer alternative to intermittent incremental doses if adequate facilities for neuromuscular monitoring are available.
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