Hepatoprotective activity of Aloe Vera extract in rodent model

Abstract

In the present study, the preliminary phytochemicals test was done on the alcoholic extract of Aloe vera leaf and it is found to be rich in Carbohydrates, Proteins, Saponin, Flavonoids and Phenolic compound. Plants have been used during the age for cure and treatment of diseases since the start of mankind. Phyto-therapy is the use of plant, plant extract or pure chemicals isolated from natural products to treat diseases. Plants have been used to treat diseases such as diabetes, jaundices, cardiovascular disease, heavy metal poisoning, congestion of abdominal and pelvic cavities and scarlet fever etc. it is evident that the plant has great potentials in treating a number of aliments where the free radicals have been reported to be the major factors contributing to the disorders (Khanzada et al., 2013). In present investigation one of traditionally used herbs anti- Hepatotoxicity being assessed against the Paracetamol induced Hepatotoxicity in rats. Silymarin-treated animals also showed a significant (p<0.001) increase in antioxidant enzymes, namely SOD, catalase, GPx activities and GSH level compared to paracetamol-treated rats. To understand the effect of the extract on liver, histology of liver was performed. Firstly, Organoleptic Characterization of plant extract was performed. Organoleptic evaluations are subjective, sensory judgments. They can involve eyeing, feeling and taste of the extract to the judge its appearance, coour, integrity, texture and flavours. The organoleptic characters of alcoholic extract of Aloe vera leaf extract were found to be dark green in colour, semi-solid, and taste is acrid. Solubility testing of alcoholic extract of Aloevera leaf is done mainly to study the ability of the dissolve in different solvent for the preparation of aqueous extract for dosing. The alcoholic extract was observed to be dissolved in water and DMSO.