Diagnostic utility of cartridge based nucleic acid amplification tests in tubercular pleural effusions
Keywords:
cbnaat, tuberculosis, extrapulmonarytb, diagnosis, pleural effusion, cartridge based nucleic acid amplification test, respiratory, medicineAbstract
Objective: To assess the utility of Cartridge Based Nucleic Acid Amplification Test in diagnosing tubercular pleural effusions.
Methods: 43 patients who attended Respiratory medicine OPD from year 2019- 2021were diagnosed as cases of tubercular pleural effusion based on clinical suspicion, radiology, biochemical and pathological investigations of pleural fluid and response to anti TB treatment. Pleural fluid sample of all patients was also subjected for CBNAAT test.
Results: Out of the 43 patients, only 4 (9.3%) patients had CBNAAT positive results. None of the CBNAAT positive had Rifampicin resistance.
Conclusion: In this study we concluded that the diagnostic value of Cartridge Based Nucleic Acid Amplification Test in tubercular pleural effusion is limited due to the low bacillary load of the effusion. Hence the initiation of anti-tubercular treatment for such cases should be based mainly on symptoms, clinical signs along with various biochemical, pathological and microbiological tests of pleural fluid.
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