Prevalence and antimicrobial resistance patterns of bacterial pathogens causing Urinary tract infection in a tertiary healthcare setting, Maldives.
Keywords:
uropathogens, antimicrobial resistance, urinary tract infectionAbstract
Objectives: To determine the prevalence and antimicrobial resistance patterns of bacterial uropathogens from culture positive sample data from a tertiary healthcare setting.
Methods: A retrospective analysis of culture isolates obtained from urine samples received at Department of Laboratory Medicine, Indira Gandhi Memorial Hospital, Male’, Maldives was performed between January 2017 and December 2017.
Results: A total of 3901 urine specimens received were analyzed and 24.1% were from males and 75.9% were from females. Escherichia coli was the most common gram-negative isolate (37.9 %) followed by Klebsiella spp (25.79%). Tested third generation cephalosporin resistances were: E. coli (male 49%, female 30%), Klebsiella spp (male 55%, female 28%). Carbapenem resistance percentages were as follows: E.coli tested against imipenem(males:33%, females:26%) and meropenem (males:44% females55%).Klebsiella spp imipenem(males 23% females 27%), and meropenem(males 35%, females 68%).
Conclusion: The high level of resistance especially to carbapenems amongst common isolates is reason to modify therapy until susceptibility testing has been carried out. Regional surveillance programs are required to gain a broader understating for surveillance and modify national guidelines
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