A Prophylactic role of soya oil against radiations damage on reproductive performance of male Albino rat
Keywords:
Soya oil, Reproductive performance, Prophylaxis, Radiation damage, Albino rat, testicular histologyAbstract
Soyabeen (Glycine max) oil is widely consumed as edible food in many countries of the world. Its versatility allows them to be incorporated into dietary substances. The radioprotective efficacy of soya oil against gamma irradiation was studied in Swiss albino rats. Rats were administered soya oil orally once a day for 15 consecutive days then exposed to the dose of 5 Gy of gamma radiations. The gamma radiations induced DNA strands break in spermatogonia, depleted in seminiferous tubules as well as other abnormalities in sperm motility, sperm count, sperm viability, and longevity, total antioxidant capacity (TAC), LH, FSH and testosterone hormones in testis. These abnormalities were markedly prevented by soya oil pretreatment. Soya oil pretreatment inhibited apoptotic signaling proteins, improving germinal epithelium deterioration believed to be injured by gamma irradiations. This produced a dose reduction factor for soya oil. The protective role of soya oil against gamma radiations may be attributed due to its constituent, the isoflavone. Isoflavone plays a significant role in scavenging of free radicals. The study highlights the gonado-protective role of soya oil against radiation induced degenerative changes in testes of swiss albino rat.
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Rozen P., Lubin F., Papo N., Knaani J., Farbstein H., Farbstein M., Zajicek G. (2001)
“Calcium supplements interact significantly with long-term diet while suppressing rectal epithelial proliferation of adenoma patients”. Cancer; 91: 833–840.
Yarube IU, Okasha MAME, Ayo JO, Olorunshola KV. “Antioxidant vitamins C and E alleviate the toxicity induced by chronic sodium nitrate administration on sperm count and serum testosterone level in Wistar rats”. Eur J Sci Res 2009; 25:35-41.
Katalinic V, Modun D, Music I, Boban M. “Gender differences in antioxidant capacity of rat tissues determined by 2,2′-azinobis (3-ethylbenzothiazoline 6-sulfonate; ABTS) and ferric reducing antioxidant power (FRAP) assays”. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 140: 47-52, 2005.
Bond VP, Fliedner TM, Archambur JO.” Mammalian Radiation Lethality”. New York, NY, USA: Academic Press; 1965. [Google Scholar]
Jagetia GC, Baliga MS. “Influence of the leaf extract of Mentha arvensis Linn. (Mint) on the survival of mice exposed to different doses of gamma radiation”. Strahlentherapie und Onkologie. 2002;178(2):91-98. [PubMed] [Google Scholar]
Cordelli E, Fresegna AM, Leter G, Eleuteri P, Spano M, Villani P. “Evaluation of DNA damage in different stages of mouse spermatogenesis after testicular X irradiation”. Radiat Res. 2003;160: 443–51.
Meistrich ML. “Effects of chemotherapy and radiotherapy on spermatogenesis”. Eur Urol. 1993; 23:136–41.
Chuai Y, Gao F, Li B, Zhao L, Qian L, Cao F, Wang L, Sun X, Cui J, Cai J. “Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals”. Biochem J. 2012; 442: 49–56.
Oakberg E. F. “Sensitivity and time of degeneration of spermatogenic cells irradiated in various stages of maturation in the mouse”. Radiat Res. 1955; 2:369–391.
Sapp W J, Philpott D E, Williams C S, Williams J W, Kato K, Miquel J M, Serova L. “Comparative study of spermatogonial survival after x-ray exposure, high LET (HZE) irradiation or spaceflight”. Adv Space Res. 1992;12: 179–189.
Shin S C, Kang YM, Jin Y W, Kim H S. “Relative morphological abnormalities of sperm in the caudal epididymis of high- and low-dose-rate gamma-irradiated ICR mice”. J Radiat Res. 2009;50: 261–266.
Hwang SY, Kim WJ, Wee JJ, et al. “Panax ginseng improves survival and sperm quality exposed to 2,3,7,8-tetrachlorodibenzo- p-dioxin”. BJU Int. 2004; 94(4): 663‒668.
Lynn KR, Skinner CJ. “Radiolysis of an alkaline phosphatase”. Radiat Res. 1974; 57:358‒363.
Agarwal A, Saleh R A, Bedaiwy M A. “Role of reactive oxygen species in the pathophysiology of human reproduction”. Fertil Steril 2003; 79: 829-843.
Sonntag C. “The Chemical Basis of Radiation Biology”. Taylor & Francis; 1987.
Monobe M, Hino M, Sumi M, Uzawa A, Hirayama R, Ando K, Kojima S. “Protective effects of melatonin on gamma-ray induced intestinal damage”. Int J Radiat Biol. 2005; 81:855–60.
Pieri C, Marra M, Moroni F, Recchioni R, Marcheselli F. “Melatonin: a peroxyl radical scavenger more effective than vitamin E”. Life Sci. 1994; 55:PL 271–276.
Marshall KA, Reiter RJ, Poeggeler B, Aruoma OI, Halliwell B. “Evaluation of the antioxidant activity of melatonin in vitro”. Free Radic Biol Med. 1996; 21:307–315.
Effects of gamma rays on rat testis tissue according to the morphological parameters and immunohistochemistry: radioprotective role of silymarin Mohsen Marzban, Maryam Anjamshoa, Parnia Jafari, Hossien Masoumi, Reza Ahadi, Daryoush Fatehi Electron Physician. 2017 Jun; 9(6): 4524–4532. Published online 2017 Jun 25. doi: 10.19082/4524.
Vijayalaxmi, Reiter RJ, Meltz ML, Herman TS. “Melatonin: possible mechanisms involved in its ‘radioprotective’ effect”. Mutat Res. 1998; 404: 187–189.
Ogilvy-Stuart AL, Shalet SM. “Effect of radiation on the human reproductive system”. Environ Health Perspect. 1993; 101: 109–116.
Rowley MJ, Leach DR, Warner GA, Heller CG. “Effect of graded doses of ionizing radiation on the human testis”. Radiat Res. 1974; 59:665–678.
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