The anti-anxiety activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by Light Dark Box Transition Test

Abstract

Background: Numerous anti-anxiety medications used nowadays have many side effects. The Withania coagulans – an uncommon species, is not studied considerably for its activities on anxiety but in the late seventies where it was discovered for neuro-psycho-pharmacological activity. Hence, it was believed praiseworthy to explore anti-anxiety actions of the alcoholic excerpt of Withania coagulans fruits in Swiss albino mice using light-dark box transition test.

Objectives: To study the alcoholic excerpt of Withania coagulans fruits’ anti-anxiety effect in Swiss albino mice using light-dark box transition test.

Methods: Light dark box transition experiment was used for assessing the anti-anxiety act of Withania coagulans fruits’ alcoholic excerpt. If the extract had an anti-anxiety effect, then it was predictable that the period consumed in the lighted area would rise and on the other hand that of the dark area would fall. This rise in time in the lighted zone, if found statistically substantial, was measured for anti-anxiety effect.

Result: There was statistically very significant (p-value < 0.001) link observed between the alcoholic excerpt of Withania coagulans fruits with anti-anxiety effect in the Swiss albino mice by light-dark box transition test.

Conclusion: The alcoholic excerpt of Withania coagulans fruits attested the anti-anxiety effect in the Swiss albino mice through the light-dark box transition test.