Biochemical analysis of Liver Function Test in different trimesters of Pregnancy
DOI:
https://doi.org/10.7439/ijbr.v10i11.5316Keywords:
Albumin, Body Mass Index, Liver function test, Pregnancy, ProteinAbstract
Background and objectives: Changes in value of certain serum liver function tests may be challenging and relies on laboratory investigations during pregnancy. So, it is important to distinguish the physiological changes or disease pathology.
Material and Methods: The case control study was carried out in Department of Biochemistry at Clinical Pathology Laboratory, Janaki Medical College Teaching Hospital, Tribhuvan University, Nepal. Cluster random sampling was adopted. Blood samples were analyzed for liver function profile and protein profile was processed with semi-automatic analyzer using clinical chemistry reagent kits. BMI was also calculated. Data were analyzed using SPSS version 20.0 and p-value < 0.05 was considered as statistically significant.
Results: The mean ALP level was slightly increased in 2nd trimester and drastically increased in 3rd trimesters during pregnancy as compared to 1st trimester as well as to non-pregnant healthy women (p=0.000). But, the mean ALT, protein and albumin level was decreased in the 2nd and 3rd trimester as compared to 1st as well as non- pregnant healthy women (p=0.004), (p=0.000) and (p=0.000) respectively. AST level was unaffected during stage of pregnancy and found to be statistically insignificant (p=0.830). BMI in pregnant women increased with the trimesters of pregnancy and was statistically significant (F=50.14, p=0.000). The minor variation in globulin in different trimesters was confirmed as compared to controls (p=0.000). BMI and ALP was positively correlated whereas albumin and total protein with BMI were negatively correlated.
Conclusion: The ALP level was significantly elevated in 3rd trimester as compared to non-pregnant healthy women. Other liver enzyme, ALT was decreased and AST was found to be unaffected. A slight variation in albumin, globulin and total protein was depicted. Thus, gynecologists should prefer LFTs as routine tests in all gestational trimesters to avoid the future complications to mother and offspring.
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