A comparative study of efficacy of propofol auto co induction versus midazolam propofol co induction using the priming principle
DOI:
https://doi.org/10.7439/ijbr.v10i5.5181Keywords:
Anaesthesiology, Propofol, Autocoinduction, Coinduction, Midazolam, Peri intubationAbstract
Background: Induction can be considered as one of the most crucial events in anaesthesiology and propofol is preferred induction agent nowadays due to its good properties. The aim of present study was to evaluate the clinical efficacy of propofol auto-co-induction compared to midazolam propofol co-induction in terms of: reduction in induction dose of propofol; and hemodynamic stability in peri-intubation period.
Method: A total of 90 patients were randomly allocated into 3 groups of 30 each. Group I received the priming agent IV propofol 0.5mg/kg, group II received 0.05 mg/kg IV midazolam and group III received 3 ml of normal saline. This was followed by IV induction with propofol 2 minutes later in all the three groups till the loss of eyelash reflex.
Results: Induction dose of propofol was significantly reduced in group II by 12.38% as compared to group I(5 %). After induction mean HR was significantly lower in group I as compared to group II and controls. Mean SBP and DBP was significantly higher in group II as compared to group I and controls in peri intubation period. While mean DBP of IV propofol group was lower than control group. Oxygen saturation was comparable among all three groups and maintained above 95% throughout the surgery. No complications were noted in any of the groups.
Conclusion: The results showed a significant decrease in induction dose requirement in both the groups but dose reduction was significantly more with midazolam. Haemodynamic stability during induction and intubation was more in propofol auto-co-induction group.
Downloads
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- An author must submit Copyright form After acceptance of the article.