Effect of Palonosetron monotherapy versus Palonosetron with Dexamethasone combination therapy for prevention of post operative nausea vomiting in children undergoing strabismus surgery
DOI:
https://doi.org/10.7439/ijbr.v10i2.5080Keywords:
Anaesthesia, brain abscess, tetralogy of fallot, surgeryAbstract
Background: Postoperative nausea and vomiting (PONV) is the most distressing symptom reported in 40 88% of patients subsequent to strabismus surgery. Newer antiemetic 5-HT3 receptor antagonist drugs palonosetron and its combination with dexamethasone for prevention PONV in chemotherapy patients having promising results, but has not been studied in children undergoing strabismus surgery.
Methodology: 120 patients were registered in this prospective, randomized double blind study. Group A received palonosetron 1.5 mcgkg-1 and Group B received an additional dose of Inj dexamethasone 0.25 mgkg-1 prior to anaesthesia. Post operative data of PONV and postoperative vomiting (POV) was recorded at pre defined intervals in different age groups.
Results: There is no difference of POV in both groups at different age groups. The incidence of post operative nausea in Group A was 44% and Group B was 11% (p=0.02).Considering the incidence of PONV in all age groups, our results showed that the overall incidence of PONV in Group A was found to be more than that with Group B (p 0.05). Also in age group 3 year to 9 year, the incidence of PONV was higher in Group A than Group B (p =0.01).The incidence of PONV was found to be 17% (6 out of 36), 21% (14 out of 68) and 6% (1 out of 16) when one, two and three extra ocular muscles were operated respectively(p=0.39).
Conclusion: Palonosetron with dexamethasone combination therapy is recommended to be used in children age > 3years undergoing strabismus surgery.
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