Efficacy of IV Lidocaine in attenuating the hemodynamic responses to laryngoscopy and intubation
DOI:
https://doi.org/10.7439/ijbr.v9i12.4988Abstract
Aims and Objectives: To determine the efficacy of IV Lidocaine in attenuating the hemodynamic responses to laryngoscopy and intubation and to statistically compare and analyse the results obtained. Materials and Methods: The study was conducted in 50 ASA I and II patients who were randomly allocated into two groups. Group I patients received IV rocuronium 1.2 mg/kg along with thiopentone induction and the pressor response to laryngoscopy and intubation was assessed at subsequent intervals in the next 10 minutes. Group II patients received IV rocuronium 1.2 mg/kg and IV Lidocaine 1.5 mg/kg along with thiopentone induction and the pressor response to laryngoscopy and intubation was assessed at subsequent intervals in the next 10 minutes. Results: Lidocaine suppresses the pressor response to laryngoscopy and intubation in the current study. Conclusion: We found out that intravenous lignocaine is effective to attenuate the pressor response if given along with induction not just before intubation.Downloads
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References
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Takki S, Tammisto P, Jaattela A. Effect of laryngoscopy and intubation on plasma cathecholamine levels during intravenous induction of anaesthesia. Br J Anaesth 1972: 44:1323.
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Tomori Z, Widdicombe JG. Muscular, bronchomotor and cardiovascular reflexes elicited by mechanical stimulation of respiratory tract. J Physiol (Lond) 1969; 200:25.
Russel WJ, Morris RG, Frewin DB, Brew SE. Changes in plasma catecholamine concentration during endotracheal intubation. Br J Anaesthesia 1981; 53:837-42.
Derbyshire Dr, Chemillewski A, Fell D, Vater M, Achola KJ, Smith G. Plasma catecholamine response to tracheal intubation. Br J Anaesthesia 1983; 55:855.
Marty J, Couture J, Dc Champlain J. Plasma sulphate conjugated catecholamine during anaesthesia. Can Anaesthesia Soc J 1983; 30:582.
Cummins NF, Rossell WJ, Frewin DB, Miller WA. The effect of gallamine and mixture of pancuronium and alcuronium on the pressor and plasma catecholamine response to tracheal intubation. Anaesth Inten Care 1984; 12:22.
Pyrs-Robers C, Feox P, Birog P, Roberts JG. Studies of anaesthesia in relation to hypertension. Br J Anaesthesia 1973; 45:671-80.
Low JH, Harvey JT, Pyrs Roberts C, Dagnini J. Studies of anaesthesia in relation to hypertension. Br J Anaesth 1986; 58:471-7.
De Quaratro V, Chan S. Raised plasma catecholamine in some patients with primary hypertension. Lancet 1972; 1:806.
Masson AHB. Pulmonary oedema during or after surgery. Anesth Analg. 1964:43:440.
Roy WL, Edelist G, Gilbert B. Myocardial ischema during non-cardiac surgical procedure in patients with coronary artery disease. Anaesthesiology 1979; 51:393-7.
Fox E, Sklar GS, Hill C. Complications related to pressor response to endotracheal intubation. Anaesthesiology 1977; 47:524.
Burney BB, Winn R. Increased cerebrospinal fluid pressure during laryngoscopy and intubation for induction of anesthesia. Anesth Analg 1975; 54:687.
Goldman L, Caldera RN. Risks of general anaesthesia and elective operation in hypertensive patient. Anaesthesiology 1979; 50:285.
Collinsworth KA, Kalmon SM Harrison DC. The clinical pharmacology of lidocaine as an anti arrhythmic drug. Circulation 1974; 50:1217-30.
Steinhaus JE, Gaskin L. A study of intravenous lidocaine as suppressant of cough reflex. Anaesthesiology 1963: 24:285.
Baraka A. Intravenous lidocaine controls extubation laryngospasm in children. Anesth Analg. 1978; 57:506-7.
Nishino T, Hiraga K, Sugimori K. Effects of iv lodocaine on airway reflexes elicited by irritation of tracheal mucosa in humans anaesthetised with enflurane. Br J Anaesth. 1990; 64:682-7.
Yukioka H, Yoshimoto N, Nishimura K, Fujimori M. Intravenous lidocaine as a suppressant of coughing during tracheal intubation. Anesth Analg. 1985;64:1189-92
Mullholland Di, Carlisle RJ. Intubation with propofol augmented with intravenous lignocaine. Anaesthesia. 1991; 46:312-3.
Abou Madi MN, Kessler H, Yacoub JM. Cardiovascular reactions to laryngoscopy and tracheal intubation following small and large intravenous dose of lidocaine. And Anaesth Soc J 1977; 24:9-12.
Helfman SM, Gold MI, DeLissor EA, Herrington CA. Which drug prevents tachycardia and hypertension associated with tracheal intubation: lidocaine, fentanyl, or esmolol? Anaesthesia Analg 1991; 72:482-6.
Feng CK, Chan KH, Ziu KN, Or CH, Zee TY. A comparison of lidocaine, fentanyl and esmolol for attenuation of cardiovascular response to laryngoscopy and tracheal intubation. Acts Anaesthesiol Sin 1996; 34:61-7.
Forbes AM, Dally EG. Acute hypertension during induction of anaesthesia and endotracheal intubation in normotensive man. Brit J Anaesth 1970; 42:618.
Takki S, Tammisto P, Jaattela A. Effect of laryngoscopy and intubation on plasma cathecholamine levels during intravenous induction of anaesthesia. Br J Anaesth 1972: 44:1323.
King BO, Harris LC, Greifenstein FE, et al. Reflex circulation responses to direct laryngoscopy and tracheal intubation performed during general anaesthesia. Anaesthesiology 1951, 12:556-566.
Tomori Z, Widdicombe JG. Muscular, bronchomotor and cardiovascular reflexes elicited by mechanical stimulation of respiratory tract. J Physiol (Lond) 1969; 200:25.
Russel WJ, Morris RG, Frewin DB, Brew SE. Changes in plasma catecholamine concentration during endotracheal intubation. Br J Anaesthesia 1981; 53:837-42.
Derbyshire Dr, Chemillewski A, Fell D, Vater M, Achola KJ, Smith G. Plasma catecholamine response to tracheal intubation. Br J Anaesthesia 1983; 55:855.
Marty J, Couture J, Dc Champlain J. Plasma sulphate conjugated catecholamine during anaesthesia. Can Anaesthesia Soc J 1983; 30:582.
Cummins NF, Rossell WJ, Frewin DB, Miller WA. The effect of gallamine and mixture of pancuronium and alcuronium on the pressor and plasma catecholamine response to tracheal intubation. Anaesth Inten Care 1984; 12:22.
Pyrs-Robers C, Feox P, Birog P, Roberts JG. Studies of anaesthesia in relation to hypertension. Br J Anaesthesia 1973; 45:671-80.
Low JH, Harvey JT, Pyrs Roberts C, Dagnini J. Studies of anaesthesia in relation to hypertension. Br J Anaesth 1986; 58:471-7.
De Quaratro V, Chan S. Raised plasma catecholamine in some patients with primary hypertension. Lancet 1972; 1:806.
Masson AHB. Pulmonary oedema during or after surgery. Anesth Analg. 1964:43:440.
Roy WL, Edelist G, Gilbert B. Myocardial ischema during non-cardiac surgical procedure in patients with coronary artery disease. Anaesthesiology 1979; 51:393-7.
Fox E, Sklar GS, Hill C. Complications related to pressor response to endotracheal intubation. Anaesthesiology 1977; 47:524.
Burney BB, Winn R. Increased cerebrospinal fluid pressure during laryngoscopy and intubation for induction of anesthesia. Anesth Analg 1975; 54:687.
Goldman L, Caldera RN. Risks of general anaesthesia and elective operation in hypertensive patient. Anaesthesiology 1979; 50:285.
Collinsworth KA, Kalmon SM Harrison DC. The clinical pharmacology of lidocaine as an anti arrhythmic drug. Circulation 1974; 50:1217-30.
Steinhaus JE, Gaskin L. A study of intravenous lidocaine as suppressant of cough reflex. Anaesthesiology 1963: 24:285.
Baraka A. Intravenous lidocaine controls extubation laryngospasm in children. Anesth Analg. 1978; 57:506-7.
Nishino T, Hiraga K, Sugimori K. Effects of iv lodocaine on airway reflexes elicited by irritation of tracheal mucosa in humans anaesthetised with enflurane. Br J Anaesth. 1990; 64:682-7.
Yukioka H, Yoshimoto N, Nishimura K, Fujimori M. Intravenous lidocaine as a suppressant of coughing during tracheal intubation. Anesth Analg. 1985;64:1189-92
Mullholland Di, Carlisle RJ. Intubation with propofol augmented with intravenous lignocaine. Anaesthesia. 1991; 46:312-3.
Abou Madi MN, Kessler H, Yacoub JM. Cardiovascular reactions to laryngoscopy and tracheal intubation following small and large intravenous dose of lidocaine. And Anaesth Soc J 1977; 24:9-12.
Helfman SM, Gold MI, DeLissor EA, Herrington CA. Which drug prevents tachycardia and hypertension associated with tracheal intubation: lidocaine, fentanyl, or esmolol? Anaesthesia Analg 1991; 72:482-6.
Feng CK, Chan KH, Ziu KN, Or CH, Zee TY. A comparison of lidocaine, fentanyl and esmolol for attenuation of cardiovascular response to laryngoscopy and tracheal intubation. Acts Anaesthesiol Sin 1996; 34:61-7.
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2018-12-28
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Efficacy of IV Lidocaine in attenuating the hemodynamic responses to laryngoscopy and intubation. Int Jour of Biomed Res [Internet]. 2018 Dec. 28 [cited 2025 Mar. 12];9(12):415-8. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/4988