Comparisons of platelet indices and angiographic findings in diabetic and non diabetics presenting with acute coronary syndrome
DOI:
https://doi.org/10.7439/ijbr.v9i10.4907Keywords:
Epidural analgesia, Ropivacaine, CardiotocographyAbstract
Introduction: Platelets with larger volume have more activity compared to smaller ones, patient with higher platelet indices have more atherogenic potential and risk for acute coronary syndromes Aim: To compare Platelet indices, RBS, RFT, Lipid profiles, Coronary angiography and other parameters in Diabetic and non-diabetic individuals who presented with ACS. Materials and methods: A prospective study with total 100 patients among that 50 were diabetics and 50 were non diabetic individuals admitted to ICCU KIMS Hubli were included. Patients with anaemia, Bleeding diathesis and malignancies were excluded from the study. All the patients underwent complete clinical examination and RBS, Platelet indices, coronary angiography and other routine parameters, were estimated and the results were analysed using SPSS 20 version. Results: Platelet indices were significantly higher in diabetic individuals compared to non-diabetics and TVD and DVD are more common in diabetics as compared to non-diabetics who were presented with ACS. Conclusion: In our study we concluded that platelet indices are higher in DM. Coronary artery disease is severe in diabetic patients compared to non-diabetic patients presenting with ACS.Downloads
References
International Diabetes Federation. IDF Diabetes Atlas. 6 ed. Brussels,
Belgium: International Diabetes Federation; 2013. Available at: http://www.idf.org/diabetesatlas.
American Diabetes Association. Classification and diagnosis of diabetes. Diabetes Care. 2015; 38: S8-S16.
Costa, S., Vinagre, C., Chacra, A. and Azevedo, M. Platelet Indices in Patients with Acute Coronary Syndrome. Journal of Biosciences and Medicines, 2015; 3: 71-76. doi: 10.4236/jbm.2015.311009
Boos CJ, Lip GY. Platelet activation and cardiovascular Outcomes in acute coronary syndromes. J Thromb Haemost 2006; 4: 2542–3.
Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of platelet Activity. Clin Appl Thromb Hemost 2003; 9:177–90.
Jesty J, Yin W, Perrotta P, Bluestein D. Platelet activation in a circulating flow loop: combined effects of shear stress and exposure time. Platelets 2003; 14:143–9.
Boos CJ, Lip GY. Assessment of mean platelet volume in coronary artery disease. Thromb Res 2006; 120:11–3.
Nguyen TA, Diodati JG, Pharand C. Resistance to clopidogrel: a review of the evidence. J Am Coll Cardiol, 2005; 45: 1157–1164.
Bath PM, Butterworth RJ. Platelet size measurement, physiology and vascular disease. Blood Coagul Fibrinolysis, 1996; 7: 157–161.
Halbmayer WM, Haushofer A, Radek J et al. Platelet size, fibrinogen and lipoprotein (a) in coronary heart disease. Coron Artery Dis, 1995; 6: 397–402.
De Luca G, Venegoni L, Iorio S et al. Novara Atherosclerosis Study Group: Platelet distribution width and the extent of coronary artery disease: results from a large prospective study. Platelets, 2010; 21: 508–514.
Lippi G, Montagnana M, Salvagno GL, Guidi GC. Potential value for new diagnostic markers in the early recognition of acute coronary syndrome. CJEM 2006 Jan; 8(1):27–31.
Boos CJ, Lip GY. Platelet activation and cardiovascular Outcomes in acute coronary syndromes. J Thromb Haemost 2006; 4(12): 2542–3.
Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of platelet Activity. Clin Appl Thromb Hemost 2003; 9(3): 177–190.
Jesty J, Yin W, and Perrotta P, Bluestein D. Platelet activation in a circulating flowloop: combined effects of shear stress and exposure time. Platelets 2003; 14(3):143–149.
Kamath S, Blann AD, Lip GY .Platelet activation: assessment and quantification. Eur Heart J 2001; 22(17):1561–71.
Lippi G, Filippozzi L, Salvagno GL, et al. Increased mean platelet volume in patients with acute coronary syndromes. Arch Pathol Lab Med. 2009;133:1441e1443
Khandekar MM, Khurana AS, Deshmukh SD, et al. Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol. 2006; 59:146e149.
Kilicli-Camur N, Demirtunc R, Konuralp C, et al. Could mean platelet volume be a predictive marker for acute myocardial infarction? Med Sci Monit. 2005;11:CR387e3918
Chu H, Chen WL, Huang CC, et al. Diagnostic performance of mean platelet volume for patients with acute coronary syndrome visiting an emergency department with acute chest pain: the Chinese scenario. Emerg Med J. 2011; 28:569e574.
Khode V, Sindhur J, Kanbur D, et al. Mean platelet volume and other platelet volume indices in patients with stable coronary artery disease and acute myocardial infarction: a case control study. J Cardiovasc Dis Res. 2012; 3: 272e275.
Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: A systematic review and meta-analysis. J Thromb Haemost. 2010; 8:148e156.
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