Salivary Cyclin D1 and Ki 67 for staging of oral cancer
DOI:
https://doi.org/10.7439/ijbr.v9i9.4895Abstract
Aims and Objectives : To study the usefulness of salivary abnormal expression of Cyclin D1 and Ki-67 proteins for staging of oral cancer. Materials and Methods: The study was approved by the Institutional Ethics Committee. Saliva was collected from each of the patients taking appropriate precautions. The vials used were sealed tightly and stored at -40 degrees. ELISA test was collected with these samples to estimate Cyclin D1 and Ki 67 levels. Results: Among the malignant oral lesions, 2 subjects had stage 1 disease, 6 subjects had stage 2 disease, 1 had stage 3 disease and 2 subjects had metastatic stage 4 disease. In the study there was no significant correlation for Stage of cancer with Cyclin D1 and Ki67 levels. Both correlations were negative, i.e. with increase in stage of cancer there was decrease in Cyclin d1 and Ki 67. Conclusion: Cyclin D1 and Ki 67 levels in saliva as a screening strategy for oral malignant lesions appears to be a very promising prospect in a quest to develop simple, reliable noninvasive tool. Both the biomarkers seem to be useful for staging of oral cancer also.Downloads
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