Oxytocin infusion versus per rectal misoprostol in the prevention of primary post partum haemorrhage in mothers with severe preeclampsia and eclampsia undergoing caesarean section at a peripheral Medical College
DOI:
https://doi.org/10.7439/ijbr.v9i8.4865Abstract
Objective: To study if misoprostol is as effective and safe as the gold standard, oxytocin, in the prevention of primary post partum haemorrhage in patients with severe preeclampsia and eclampsia undergoing caesarean section.
Method: One hundred patients with severe preeclampsia and eclampsia scheduled for caesarean section were recruited in a prospective randomized interventional trial to receive either oxytocin infusion (10IU in 500 ml Ringers lactate at 100cc/hr) or 600 ug per rectal misoprostol after delivery. Blood loss in 24 hrs after delivery, haemoglobin and haematocrit before and 24 hrs after delivery, need for additional oxytocic therapy and incidence of side effects were noted.
Results: The mean blood loss (P = 0.712), drop in haemoglobin (P = 0.294), haematocrit (P = 0.768) and need for additional carboprost (P = 0.749), even though slightly higher in the group receiving misprostol, were not statistically significant. The incidence of shivering (P = 0.011) and fever (P = 0.044) were significantly more in the misoprostol group. These were however self limiting and mild.
Conclusion: Misoprostol can be used as an effective alternative to oxytocin where availability and storage of the latter is difficult and its side effects were not serious.
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