Liver function assessment in Glucose-6-Phosphate Dehydrogenase deficient neonates in Benin

Authors

  • Fiogbe E. M. Salomon Research Laboratory in Applied Biology, "EcolePolytechniqued’Abomey-Calavi", University of Abomey-Calavi, Benin, 01BP 2009 Cotonou
  • Akpovi D. Casimir - University of Abomey-Calavi (Benin)- University of Montreal (Canada)
  • Segbo A.G. Julien Research Laboratory in Applied Biology, "EcolePolytechniqued’Abomey-Calavi", University of Abomey-Calavi, Benin, 01BP 2009 Cotonou
  • Bognon Gilles Medical Genetics and Neonatology, "Centre National Hospitalier et Universitaire H.K. Maga", 01BP 386, Cotonou
  • Medehouenou T.C. Marc Research Laboratory in Applied Biology, "EcolePolytechniqued’Abomey-Calavi", University of Abomey-Calavi, Benin, 01BP 2009 Cotonou
  • Sagbo G. Gratien Medical Genetics and Neonatology, "Centre National Hospitalier et Universitaire H.K. Maga", 01BP 386, Cotonou
  • Agbangla Clement Laboratory of Molecular Genetics and Genome Analyzes, Faculty of Sciences and Technics, University of Abomey-Calavi, 01BP 526, Cotonou

Keywords:

Sebaceous carcinoma, eyelid, Meibomian glands

Abstract

Background : Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the major underlying causes of jaundice in neonates. However, the exact cause of the hyperbilirubinemia is still unknown. This study was aimed to assess liver function in G6PD deficient neonates. Methods : This study was carried out as a pre-posttest design study with a control group. A total of 410 neonates aged 7 days were included in the study. Intra-erythrocyte G6PD activity was determined by quantitative enzymatic method. Plasma glucose, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity, direct and total bilirubin, calcium (Ca2+) and magnesium (Mg2+) levels were measured using ELITech reagents. Hematological analyses were performed using an automatic hematological analyzer. Results : Of the 410 neonates, 101 (24.63%) were G6PD-deficient with no significant difference between gender (male, 49 (11.95%); female, 52 (12.68%). G6PD activity level was significantly (p ˂0.001) decreased in G6PD-deficient male (2.06

Downloads

Download data is not yet available.

Author Biography

  • Akpovi D. Casimir, - University of Abomey-Calavi (Benin)- University of Montreal (Canada)

    Atlantique-Littoral

References

WHO Working Group. Glucose-6-phosphate dehydrogenase deficiency. Bull World Health Org. 1989; 67: 601-11.

Halamek LP, Stevenson DK. Neonatal jaundice and liver disease. In: Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant. 7th ed. St. Louis: CV Mosby; 2006; p. 1309-50.

Maisels MJ. Jaundice. In: MacDonald MG, Mullett MD, Seshia MMK, editors. Avery's Neonatology: Pathophysiology and Management of the Newborn. 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2006. p. 802-4.

Kaplan M, Hammerman C. Glucose-6-phosphate dehydrogenase deficiency: a potential source of severe neonatal hyperbilirubinaemia and kernicterus. Semin. Neonatol. 2002; 7(2):121-8.

Slusher TM, Vreman HJ, McLaren DW, Lewison LJ, Brown AK, Stevenson DK. Glucose-6-phosphate dehydrogenase deficiency and carboxyhemoglobin concentrations associated with bilirubin-related morbidity and death in Nigerian infants. J Pediatr. 1995; 126(1):102-108

Iolascon A, Faienza MF, Perrotta S, et al. Gilbert’s syndrome and jaundice in glucose-6-phosphate dehydrogenase deficient neonates. Haematol. 1999; 84:99-102.

Kaplan M, Hammerman C. Severe neonatal hyperbilirubinemia. A potential complication of glucose-6-phosphate dehydrogenase deficiency. Clin Perinatol. 1998; 25:575-90.

Valaes T. Severe neonatal jaundice associated with glucose-6-phosphate dehydrogenase deficiency: Pathogenesis and global epidemiology. Acta Paediatr. 1994; 394:58–76.

Dhillon AS, Darbyshire PJ, Williams MD, Bissenden JG. Massive acute hemolysis in neonates with glucose-6-phosphate dehydrogenase deficiency. Arch Dis Child Fetal Neonatal Ed 2003; 88(6): F534-36.

Mehta A, Mason PJ, Vulliamy TJ. Glucose-6-phosphate dehydrogenase deficiency. Best Practice and Research Clinical Haematol. 2000; 13(1):21-38.

Algur N, Avraham I, Hammerman C, and Kaplan M. Quantitative Neonatal Glucose-6-Phosphate Dehydrogenase Screening: Distribution, Reference Values, and Classification by Phenotype. J Pediatr 2012; 161:197-200.

LaRue N, Kann M, Murray M, Leader BT, Bansil P, McGray S, et al. Comparison of quantitative and qualitative tests for glucose-6-phosphate deficiency . Am J Trop Med Hyg. 2014; 91: 854-61.

Kaplan M, Hammerman C. The need for neonatal glucose-6-phosphate dehydrogenase screening: a global perspective. J Perinatol 2009; 29:S46-S52.

Minucci A, Moradkhani K, Hwang MJ, Zuppi C, Giardina B, Capoluongo E. Glucose-6-phosphate dehydrogenase (G6PD) mutations database: review of the “old” and update of the new mutations. Blood Cells Mol Dis. 2012; 48:154-65.

Riskin A, Kugelman A, Bader D. Intermediate values of glucose-6-phosphate dehydrogenase reply. J Pediatr. 2012; 161(3): 571-2.

Joseph R, Ho LY, Gomez JM, Rajdurai VS, Sivasankaran S, Yip YY. Mass newborn screening for glucose-6-phosphate dehydrogenase deficiency in Singapore. Southeast Asian J Trop Med Public Health. 1990: 30: 70-71.

Badens C, Leclaire M, Collomb J et al. Glucose-6-phosphate dehydrogenase and neonatal jaundice. Presse Med. 2001; 30(11): 524-26.

Washington EC, Ector W, Abboud M, Ohning B, Holden M. Hemolytic jaundice due to G6PD deficiency causing kernicterus in a female newborn. South Med. 1995; 88:776.

Orimadegun AE and Sodeinde O. Glucose-6-phosphate dehydrogenase status and severity of malarial anaemia in Nigerian children. J Infect Dev Ctries. 2011; 5: 792-798.

Kamran Moradkhani. Clinical heterogeneity of G6PD deficiency: New variants and Correlation between genotype and phenotype, results of a five-year-survey; CHU Henri Mondor - Creteil Dorys 2011 Strasbourg.

Carette C, Dubois-Laforgue D, Gautier JF, Timsit J. Diabetes mellitus and glucose-6-phosphate dehydrogenase deficiency: from one crisis to another. Diabetes Metab. 2011; 37: 79-82.

Carette C, Dubois-Laforgue D, Gautier JF, Timsit J. Diabetes mellitus and glucose-6-phosphate dehydrogenase deficiency: from one crisis to another. Diabetes Metab. 2011; 37: 79-82.

Nair PA, Al Khusaiby SM. Kernicterus and G6PD deficiency- a case series from Oman. J Trop Pediatr. 2003; 49(2): 74-77.

Valaes T. Severe neonatal jaundice associated with glucose-6-phosphate dehydrogenase deficiency: Pathogenesis and global epidemiology. Acta Paediatr. 1994; 394: 58–76.

Dhillon AS, Darbyshire PJ, Williams MD, Bissenden JG. Massive acute hemolysis in neonates with glucose-6-phosphate dehydrogenase deficiency. Arch Dis Child Fetal Neonatal Ed 2003; 88(6): F534-36.

Rosenthal P, Haight M. Aminotransferase as a prognostic index in infants with liver disease. Clin Chem. 1990; 36: 346-8.

Mehta A, Mason PJ, Vulliamy TJ. Glucose-6-phosphate Dehydrogenase Deficiency. Balliers Best Prac Res Clin Heamatol. 2000; 13: 2.

Wolach B, Ashkenazi M, Grossmann R, Gavrieli R, Friedman Z, Bashan N et al. Diurnal fluctuation of leukocyte G6PD activity. A possible explanation for the normal neutrophil bactericidal activity and the low incidence of pyogenic infections in patients with severe G6PD deficiency in Israel. Pediatr Res. 2004; 55:807-13

Zareifar S, Pishva N, Farahmandfar M, Benaei S, Cohan N. Prevalence of G6PD Deficiency in Neonatal Sepsis in Iran. Iran J Pediatr. 2014; 24:115-6.

Wu YH, Tseng CP, Cheng ML, Ho HY, Shih SR, Chiu DT. Glucose-6-phosphate dehydrogenase deficiency enhances human coronavirus 229E infection. J Infect Dis. 2008; 197:812-6.

Aminzadeh Z, Parsa E. Relationship between Age and Peripheral White Blood Cell Count in Patients with Sepsis. Int J Prev Med. 2011; 2:238-42.

Downloads

Published

2018-06-28

Issue

Vol. 9 No. 6 (2018): Jun

Section

Original Research Articles

License

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
  • An author must submit Copyright form After acceptance of the article.

How to Cite

1.
Liver function assessment in Glucose-6-Phosphate Dehydrogenase deficient neonates in Benin. Int Jour of Biomed Res [Internet]. 2018 Jun. 28 [cited 2025 Mar. 12];9(6):221-5. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/4750