Prevalence of Metallo-?-Lactamase producing Pseudomonas aeruginosa in tertiary care center (BPKIHS)
Keywords:
Antimicrobial resistanceAbstract
Background: Carbapenem resistance in Pseudomonas aeruginosa is an emerging threat and matter of concern, therefore detection of metallo-?-Lactamase (MBL) - producing P. aeruginosa is crucial in preventing its spread to other Gram negative bacteria.
Aims and Objective: To determine the prevalence of MBL production and antimicrobial resistance in P. aeruginosa isolated from in-patients and out-patients of a tertiary care center in Eastern Nepal.
Methodology: Identification and antimicrobial susceptibility pattern of isolated P. aeruginosa from different clinical samples received in Microbiology laboratory was performed following CLSI guidelines and MBL production was determined by IPM-EDTA - disk synergy test.
Results: A total of 137 P. aeruginosa strains were isolated from different clinical samples, out of which79.6% isolates were resistant to Carbapenem, among them 35.78% isolates were MBL producer. Overall prevalence of MBL production among P. aeruginosa was found to be 31.4%.
Conclusion: This study reveal high level of resistance being exhibited by a notorious organism like P. aeruginosa to commonly used antimicrobials for treatment of infection , and an alarming threat of MBL production necessitating a routine screening for MBL production. Also a more effective, less toxic and cheap antimicrobial for the future is imperative.
Downloads
Downloads
Published
Issue
Section
License
Copyright (c) 2018 International Journal of Biomedical Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- An author must submit Copyright form After acceptance of the article.