Vitiligo and its association with hypoacusis: A case control study
DOI:
https://doi.org/10.7439/ijbr.v8i10.4394Keywords:
Medicine out patients, Prescription, Drug utilizationAbstract
Vitiligo is a pigmentary disorder with absence of functional melanocytes in the affected area. Melanocytes originate from neural crest and migrate to rest of the body in a cephalo-caudal manner in the embryonic life. Apart from epidermis and hair bulb in skin, they are also present in leptomeninges, inner ear, retina and uveal tract. In the inner ear melanocytes are present in endolymphatic sac, hair cells, vestibular organ and striavascularis. Vitiligo is not just skin deep and is also responsible for subclinical hypoacusis in majority of patients. Patients suffering from vitiligo affecting the head and neck region at the time of origin are more prone to the auditory dysfunction. Leucotrichia is another association with asymptomatic sensori-neural hypoacusis. This is due to the loss of melanocytes which have a protective role in inner ear. TEOAE and Pure tone audiometry can be used effectively for screening patients and these patients should be informed regarding the noise exposure and ototoxic drugs.Downloads
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. Sun XK, Xu AE, Meng W, Wei XD, Jiang ZM, Yan XF et al. Study on genetic epidemiology in 815 patients with vitiligo in Zhejiang area. J Eur Acad Dermatol. 2005; 26(11):911
. Alkhateeb A, Fain PR, Thody A, Bennett DC, Spritz RA. Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families. Pigment Cell Res. 2003; 16:208-214.
. Mills MD, Albert DM. Ocular and otic findings in vitiligo. In: Hann SK, Nordlund JJ, eds. Oxford: Blackwell Science Ltd.; 2000:81-8.
. Sharma L, Bhawan R, Jain RK. Hypoacusis in vitiligo. Indian J Dermatol Venereol Leprol. 2004; 70:162-4.
. Cowan CL Jr, Halder RM, Grimes PE. Ocular disturbances in vitiligo. J Am Acad Dermatol. 1986; 15:17-24.
. Ozuer MZ, Sahiner T, Aktan S. Auditory evoked potentials in vitiligo patients. Scand Audiol. 1998; 27:255-8.
. Ortonne JP, Bose SK. Vitiligo: where do we stand? Pigment Cell Res. 1993; 6:61-72.
. Hann S-K, Nordlund JJ. Definition of Vitiligo. In: Hann S-K, Nordlund JJ eds. Vitiligo: A monograph on the basic and clinical science. Blackwell Science, Oxford, 2000:3-5.
. Steel KP, Barkway C. Another role for melanocytes: their importance for normal striavascularis development in the mammalian inner ear. Development. 1989; 107:453-63.
. Akay BN, Bozkir M, Anadolu Y, Gullu S. Epidemiology of vitiligo, associated autoimmune diseases and audiological abnormalities: Ankara study of 80 patients in Turkey. J Eur Acad. Dermatol Venereol. 2010; 24:1144-50.
. Karsai LK, Bergman M, Choo YB. Hearing in ethnically different longshoremen. Arch Otolaryngol. 1972; 96:499-504.
. Ortonne JP, Bahadoran P, Fitzpatrick TB, Mosher DB, Hori Y. Hypomelanoses and hypermelanosis. In : Freedman IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, editors. Fitzpatrick's Dermatology in General Medicine. McGraw Hill: New York; 2003. p. 836-81.
. Aslan S, Serarslan G, Teksoz E, Dagli S. Audiological and transient evoked otoacoustic
emission findings in patients with vitiligo. Otolaryngol Head Neck Surg. 2010; 142:409-14.
. Halaban R, Heberi DN. Biology of melanin. In: Fitzpatrick
. Goldgeier MH, Klein LE, Klein-Angerer S, Moellmann G, Nordlund JJ. The distribution of melanocyte in the leptomeninges of the human brain. J Invest Dermatol. 1984; 82(3):235-8.
. Spritz RA. The genetics of generalized vitiligo and associated autoimmune diseases. J ematol Sci. 2006; 41:3-10.
. Barrenas ML, Axelsson A. The development of melanin in the stria vascularis of the gerbil. Acta Otolaryngol. 1992; 112:50-8.
. McGinness J, Corry P, Proctor P. Amorphous semiconductor switching in melanins. Science 1974; 183(4127):853-5.
. Conlee JW, Parks TN, Creel DJ. Reduced neuronal size and dendritic length in the medial superior olivary nucleus of albino rabbits. Brain Res. 1986; 363:28-37.
. LaFerriere KA, Kaufman-Arenberg I, Hawkins JE, Johnsson LG. Melanocytes of the vestibular labyrinth and their relationship to microvasculature. Ann Otol Rhinol Laryngol. 1974; 83:685-94.
. Hilding D, Ginzberg R. Pigmentation of the stria vascular is. Acta Otolaryngol. 1977; 84:24-37.
. Garber SR, Turner CW, Creel DJ, Witkop CJ. Auditory system abnormalities in human albinos. Ear Hear. 1982; 3:207-11.
. Hann SK, Chun WH, Park YK. Clinical characteristics of progressive vitiligo. Int J Dermatol. 1997; 36:353-355.
. Handa S, Kaur I. Vitiligo: clinical findings in 1436 patients. J Dermatol. 1999; 26:1295-7.
. Arican O, Koc K, Kutluk R, Ersoy L. Vitiligoluhastalarda serum vitamin B12 vefolikasitduzeyleri. Turkiye Klinikleri Dermatol. 2003; 13:4-10.
. Hong CK, Lee MH, Jeong KH, Cha CI, Yeo SG: Clinical analysis of hearing levels in vitiligo patients. Eur J Dermatol. 2009; 19:50-56.
. El-SayedShalaby M, El-Zarea GA, Nassar AI. Auditory Function In Vitiligo Patients. Egyptian Dermatology Online Journal. 2006; 2(1):7.
. Fleissig E, Gross M, Ophir I, Elidan J, Bdolah-Abram T, Ingber A. Risk of Sensorineural Hearing Loss in Patients with Vitiligo. Audiol Neurotol.2013; 18:240-6.
. Ayodogan K, Turan OF, Onart S, Karadogan SK, Tunali S: audiological abnormalities in patients with vitiligo. Clin Exp Dermatol 2006; 31:110-3.
. Sharifian MR, Maleki M, Honarvar H. The correlation between vitiligo and hearing loss. Iranian J Otorhinolaryngol. 2006; 17(42):3-7.
. Bassiouny A, Farid S, El Khousht M. Hearingabnormalities in vitiligo. Egypt. J Otolaryngol.1998; 15(1):51-60.
. Schrott A, Spoendlin H. Pigment anomaly associated inner ear deafness. Acta Otolaryngol(Stockh). 1987; 103:451-7.
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