Peptic Ulcer aetiology ; role of H,K-ATPase enzyme and biochemical mediators in a reserpine induced ulcer model

Abstract

Gastric ulcers of the stomach are a serious disorder which if untreated could lead to some times life threating consequences. In hypergastrinemic states such as Zollinger-Ellison syndrome, or where acid secretion has to be inhibited by more than 20% over a 24-hr period, such as for treatment of esophagitis, NSAID damage, or gastric ulcers, the dose and frequency of administration of the currently available antagonists must be increased to achieve curative therapy. This has opened the avenues to search for an alternative target for acid inhibitory drugs, such as the gastric acid pump, the H,K-ATPase enzyme. This article focuses on the function of this ATPase and suggests that inhibition of this pump will provide a more efficacious means of reduction of acid secretion by the stomach, hence improving and simplifying therapy of acid related diseases. It also examines the effect of PUFA containing oils and conventional antacid drugs on the biochemical parameters in the reserpine induced ulcers in the rat.