Lipid profile in type 2 diabetic subjects aged 40 years and over living in Benin

Authors

  • Casimir D. Akpovi University of Abomey-Calavi (Benin) University of Montreal (Canada)
  • Segbo A.G. Julien Department of Human Biology Engineering, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi
  • Medehouenou T.C. Marc Department of Human Biology Engineering, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi
  • Anago A.A. Eugenie Department of Human Biology Engineering, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi
  • Akakpo B. Huguette Department of Human Biology Engineering, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi
  • Frederic Loko Department of Human Biology Engineering, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi

DOI:

https://doi.org/10.7439/ijbr.v6i10.2617

Abstract

Background : Abnormal lipid profile is common in subjects with type 2 diabetes (T2D). Despite use of lipid-lowering agents, many subjects with T2D do not achieve lipid targets. The present work aimed to assess lipid profile in a randomly selected group of adult diabetic subjects under treatment in order to determine how diabetes treatment affects blood lipid parameters levels. HbA1c level is used as a biomarker of glycaemia control achievement and treatment success in diabetic. Methods : This study was carried out as a pre-post test design study with a control group. A total of 117 diabetic subjects under treatment and 100 non-diabetics as control subjects are included in the study. CT, TG and HDL-C were measured by enzymatic methods and LDL-C was determined by Friedewald formula. Plasma glucose was measured by Glucose Oxidase method and glycated hemoglobin (HbA1c) with a radioimmunoassay. Results : The results showed that CT (p 0.001), LDLc (p 0.001) and TG (p=0.02) levels increased significantly in diabetics compared to controls. Atherogenic indices TC/HDL-C (p 0.01) and LDL-C/HDL-C (p 0.01), and blood calcium level (p 0.001) were significantly increased in diabetics than in controls. Subjects with HbA1c value >7.0% had significantly higher levels of TC (P 0.01), LDL-C (p 0.05), TC/HDL-C (p 0.01), LDL-C/HDL-C (p=0.02), TG/HDL-C (p=0.01) and calcemia (p 0.001) compared to subjects with HbA1c ?7.0%. Conclusion : Significant difference of lipid parameters was observed in diabetics with HbA1c ?7.0% and >7.0%. Abnormal lipid patterns and insulin resistance tend to be normalized with therapy of diabetes.

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Author Biography

  • Casimir D. Akpovi, University of Abomey-Calavi (Benin) University of Montreal (Canada)
    Atlantique-Littoral

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Published

2015-10-30

Issue

Vol. 6 No. 10 (2015): Oct

Section

Original Research Articles

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How to Cite

1.
Lipid profile in type 2 diabetic subjects aged 40 years and over living in Benin. Int Jour of Biomed Res [Internet]. 2015 Oct. 30 [cited 2024 Oct. 18];6(10):805-10. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/2617

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