Routine Cytogenetic Analysis of Chromosome Abnormalities in Acute Lymphoblastic Leukemia

Authors

  • Chin Yuet Meng Cytogenetics Laboratory, Hematology Unit, Institute for Medical Research, Kuala Lumpur,

DOI:

https://doi.org/10.7439/ijbr.v6i9.2456

Keywords:

Blood pressure, Eachocardiography, LVMI, Prehypertension.

Abstract

Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Acquired chromosomal and genetic abnormalities have been used to define distinct biological and clinical subtypes of ALL. These aberrations have been shown to be associated with patient outcome and are used to direct therapy. Conventional cytogenetics analysis (CCA) is currently the gold standard to detect chromosome abnormalities in hematological malignancies. In this review we briefly describe the CCA methodology, advantages and limitations of CCA, the main chromosomal abnormalities and their prognostic significance in ALL.

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Published

2015-09-30

Issue

Vol. 6 No. 9 (2015): Sep

Section

Review Article

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How to Cite

1.
Routine Cytogenetic Analysis of Chromosome Abnormalities in Acute Lymphoblastic Leukemia. Int Jour of Biomed Res [Internet]. 2015 Sep. 30 [cited 2025 Mar. 12];6(9):612-9. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/2456