Incidence of carbapenem-resistant pseudomonas aeruginosa in clinical samples

Abstract

Background: Pseudomonas aeruginosa have been reported to show resistance to carbapenem drugs. Detection of carbapenem resistance pseudomonas is now important to prevent their spread as discriminates of these bacteria could be fetal to the hospitalized patients. The main objective of this study was to detection of carbapenem resistant pseudomonas aeruginosa. We also aimed to search for the treatment option for this multidrug resistant P.aeruginosa. Method: A present study was conducted over a period of 6 months. 239 isolates of Pseudomonas aeruginosa were obtained from the samples from hospitals of Pt.J.N.M.Medical College, Raipur (C.G.) from January 2015 to June 2015. These isolates were tested for susceptibility to antipseudomonal drugs and considered to be resistant to carbapenem .When the zone of inhibition around imipenem and meropenem discs was 13mm. Antibiogram generated by disc diffusion susceptibility testing for clinically relevant antibiotics. Results: Out of total 239 Pseudomonas aeruginosa isolates, 25(10.46%) were found to be carbapenem resistant. All imipenem resistant isolates sensitive to polymyxin B (300g) and colistin (10g). Conclusion: The rapid dissemination of carbapenem resistance is worrisome and calls for the implementation of surveillance studies as well as judicious use of antibiotics. This therapeutic challenge to the clinicians and also need proper selection of antibiotics especially carbapenems.