Association between Lipid Profile and Ovarian Cancer in women of North India

Abstract

Objective: The aim of this study is to compare serum lipid profiles: total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) and very low density lipoprotein cholesterol (VLDL-c) and lipid ratio among ovarian cancer patients and healthy controls. Methods: Total 300 subjects were enrolled in this study. Study group comprised of 150 clinically and histologically proved cases of ovarian carcinoma and 150 healthy women recruited as a control group. Plasma levels of TC, TG, LDL-cholesterol and HDL-cholesterol, VLDL and the ratio of lipid profile were estimated by using semi-autoanalyzer. Results: In our study, we found the higher level of mean serum cholesterol, TGs, LDL-c and VLDL in ovarian cancer patients as compared to the controls. The HDL level is higher in controls as compared to study group. TGs, HDL-c VLDL were found highly significant in OC patients as compared to controls. The Ratio of TC/HDL, LDL/HDL, HDL/LDL was also found significantly higher in OC patients as compared to controls. Conclusions: The results of the present study show that plasmalipidlevels, except HDL-cholesterol, are increase in OC. As there is an alteration in the plasmalipidprofileduring gynecologic cancers, it may be helpful for diagnosis of the disease. Further studies to group important factors including, cancer stages and type of cancer, parity, and menopausal status that may affect lipid profiles in OC patients along with an investigation of new lipid profiles to clarify most lipid factors that may involve in OC development are needed.