A comparative study of haemodynamic responses to intubation: Dexmedetomidine 1g/kg VS Clonidine 1 g/kg

Abstract

Objectives: To compare the effects of Dexmedetomidine (1g/kg) and Clonidine (1g/kg) on hemodynamic responses to endotracheal intubation, effect on anaesthetic requirements and effect on sedation. Material and Methods: In this prospective double-blind study, 60 patients scheduled for elective surgeries under general anesthesia were randomly divided into two groups Group D ( Inj. Dexmedetomidine dose 1?g/kg iv) and Group C ( Inj. Clonidine dose 1?g/kg iv). Patients belonging to ASA I and ASA II of both sexes aged 20-60 years, were included in this comparative randomized study. Pulse, blood pressure, ECG were monitored continuously and recorded before giving the study drug , after giving the study drug , at intubation then at1,3,5,10 minutes after intubation. Data were analysed and p 0.05 was considered significant. Result: Dexmedetomidine group had 4.70% rise in heart rate at time of intubation and Clonidine group had 9.59% rise which was statistically significant(p 0.05), except during intubation, difference in heart rate between two groups was not significant.(p>0.05)) Group C had significant rise in SBP and DBP during intubation compared to Group D. Maximum rise in SBP and DBP in Group C was 14.53% and 12.84% respectively, whereas in Group D it was 5.55% and 8.90% respectively. Dexmedetomidine group had better sedation than Clonidine group.(p 0.05) Conclusion: Dexmedetomidine significantly attenuated the sympathetic response of laryngoscopy and intubation as compared to Clonidine.