Altered thyroid profile in metabolic syndrome

Abstract

Objectives The study was intended to access metabolic syndrome in hypothyroid patients and to investigate the association between hypothyroidism and metabolism syndrome inMeerut district. Methods The study was done on patients with symptoms of hypothyroidism or follow up cases of hypothyroidism having metabolic syndrome. T₃, T₄ and TSH were analysed by enzyme linked fluorescent assay (ELFA) technique using Minividas auto analyser fromBiomeriuex,France. Fasting blood sugar and lipid profile were estimated by Vitros-250 auto analyser using readymade dry chemistry kits from Ortho-Clinical diagnostics,Johnsonand Johnson,USA. The data was analysed using SPSS-16 software package. Result In overt hypothyroid cases T₃ values were found to be negatively correlated with waist circumference (WC), diastolic BP, FBS and TG level and positively correlated with FBS (p=0.03, r=0.24) in subclinical hypothyroidism. T₄ values negatively correlated with FBS and TG level in overt hypothyroid group and with WC, systolic and diastolic BP in subclinical group. But there was significant positive correlation with TG levels (p=0.04, r = 0.23). TSH values shows negative correlation with WC, FBS, TG and HDL levels in overt hypothyroidism. Conclusion This study on metabolic syndrome in thyroid dysfunction population may help us to plan management strategies, resulting in significant reduction in cardiovascular morbidity and mortality due to metabolic syndrome.