Antiphospholipid Syndrome - A silent killer

Authors

  • Vidyadhar B Bangal Professor and Head, Dept. of Obstetrics and Gynaecology, Rural Medical College, Loni, Maharashtra,
  • Shravani Chalasani Postgraduate Student (MS) Dept. of Obstetrics and Gynecology Rural Medical College of Pravara Institute of Medical Sciences (Deemed University) Loni, Maharashtra,
  • Denita Fernandes Postgraduate Student (MS) Dept. of Obstetrics and Gynecology Rural Medical College of Pravara Institute of Medical Sciences (Deemed University) Loni, Maharashtra
  • Pushpanjali Singh Postgraduate Student (MS) Dept. of Obstetrics and Gynecology Rural Medical College of Pravara Institute of Medical Sciences (Deemed University) Loni, Maharashtra,
  • Kanika Gupta Postgraduate Student (MS) Dept. of Obstetrics and Gynecology Rural Medical College of Pravara Institute of Medical Sciences (Deemed University) Loni, Maharashtra

DOI:

https://doi.org/10.7439/ijbr.v5i11.793

Abstract

Antiphospholipid Syndrome (APS) is a multisystem autoimmune disorder characterized by venous thrombosis, recurrent pregnancy loss, fetal death and presence of antiphospholipid antibodies (apla).The entity remains hidden unless suspected and investigated by the clinician. The target antigens of the antibodies are phospholipid binding proteins. By binding the phospholipids expressed by the trophoblasts, aPLA inhibit successful embryonic implantation into the endometrium. APS can be treated by combination of aspirin and heparin. The combination promotes successful embryonic implantation in the early stages of pregnancy and prevents thrombosis of the uteroplacental vasculature after placentation. Low molecular weight heparin has found to be more convenient , safe and effective in treatment of antiphospholipid antibody syndrome and inherited and acquired thrombophilias.

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Author Biography

  • Vidyadhar B Bangal, Professor and Head, Dept. of Obstetrics and Gynaecology, Rural Medical College, Loni, Maharashtra,
    Professor and Head, Dept. of Obstetrics and Gynaecology, Rural Medical College, Loni, Maharashtra,

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Published

2014-11-30

Issue

Vol. 5 No. 11 (2014): Nov

Section

Original Research Articles

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How to Cite

1.
Antiphospholipid Syndrome - A silent killer. Int Jour of Biomed Res [Internet]. 2014 Nov. 30 [cited 2025 Mar. 12];5(11):671-2. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/1104