Combining Artesunate-Amodiaquine and Ciprofloxacin Improves Serum Lipid Profile of Mice Exposed to Plasmodium Berghei Berghei

Authors

  • Anthony Fidelis Uwah Department of Biochemistry, College of Health Sciences, University of Uyo, P. M. B. 1017, Uyo Akwa Ibom State, Nigeria.
  • Anthony Fidelis Uwah Department of Biochemistry, College of Health Sciences, University of Uyo, P. M. B. 1017, Uyo Akwa Ibom State, Nigeria.
  • Jessie Ibongesit Ndem Department of Biochemistry, College of Health Sciences, University of Uyo, P. M. B. 1017, Uyo Akwa Ibom State, Nigeria.
  • Enomfon Jonah Akpan Department of Biochemistry, College of Health Sciences, University of Uyo, P. M. B. 1017, Uyo Akwa Ibom State, Nigeria.

DOI:

https://doi.org/10.7439/ijbr.v5i8.683

Abstract

We investigated the effects of combining artesunate-amodiaquine and ciprofloxacin on the serum lipid profile of mice exposed to Plasmodium berghei berghei . The use of this combination for the treatment of febrile illness, suspected malaria and malaria-typhoid coinfection is very common in Nigeria. 60 adult mice and Plasmodium berghei berghei were used in this study. Calculated amount of the drugs was administered orally based on dosages of 4mg/kg body weight of Artesunate, 10mg/kg body weight of amodiaquine and 9mg/Kg body weight of ciprofloxacin. The drugs were administered in two divided doses for 3 and 5 days for ACT and ciprofloxacin respectively. The result of our study showed that treatment with the combination of ACT and ciprofloxacin improved serum TG levels better than groups treated with either ACT or ciprofloxacin alone. There were significant (p 0.05) increases in the HDL-chol and insignificant (p>0.05) changes in VLDL-chol and LDL-chol of groups treated with ACT and ciprofloxacin only in comparison with the normal control. Animals treated with ACT plus ciprofloxacin showed insignificant (p>0.05) increases in all fractions of cholesterol tested in comparison to the normal control. All parameters in treated groups tested showed significant increases when compared to the parasitized untreated animals. The result of our study showed that the use of this triple regimen in management of malaria restored the lipid profile deranged by the disease better than either ACT or ciprofloxacin alone. Although synergism in the drugs action may be considered, the actual mechanism is a matter of further research.

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Author Biographies

  • Anthony Fidelis Uwah, Department of Biochemistry, College of Health Sciences, University of Uyo, P. M. B. 1017, Uyo Akwa Ibom State, Nigeria.
    Department of Biochemistry, lecturer 1
  • Anthony Fidelis Uwah, Department of Biochemistry, College of Health Sciences, University of Uyo, P. M. B. 1017, Uyo Akwa Ibom State, Nigeria.
    Department of Biochemistry lecturer 1.
  • Jessie Ibongesit Ndem, Department of Biochemistry, College of Health Sciences, University of Uyo, P. M. B. 1017, Uyo Akwa Ibom State, Nigeria.
    biochemistry lecturer 1
  • Enomfon Jonah Akpan, Department of Biochemistry, College of Health Sciences, University of Uyo, P. M. B. 1017, Uyo Akwa Ibom State, Nigeria.
    Department of Biochemistry, Professor

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Published

2014-08-30

Issue

Vol. 5 No. 8 (2014): Aug

Section

Original Research Articles

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How to Cite

1.
Combining Artesunate-Amodiaquine and Ciprofloxacin Improves Serum Lipid Profile of Mice Exposed to Plasmodium Berghei Berghei. Int Jour of Biomed Res [Internet]. 2014 Aug. 30 [cited 2026 Mar. 29];5(8):487-9. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/1049