Evaluation of effective Medhya formulation on trancranial treatment on rat

Abstract

The herbs that promote the intelligence are called Medhya herbs. This action is related to our mind and mind resides in the brain and nervous system - especially the higher cortical centers of the brain. According to Ayurveda the intelligence is a triad of three powers of the mind - the acquisition, the retention and the recollection. The unique anatomical arrangement of blood vessels and sinuses in the human skull and the brain, the prevalence of a high density of skin appendages in the scalp, extra cranial vessels of the scalp communicating with the brain via emissary veins and most importantly, the way that the scalp is used in the Ayurvedic medical system in treating diseases associated with the brain show that a drug could be transcranially deliveredand targeted to the brain through the scalp. The present study objective is to find out the effectiveness of the few medhya (polyphyto) formulations for its learning and memory activity could be delivered and targeted to the brain by transcranial delivery route. The transcranial medhya formulation; FM1 ( Habiscus rosasinensis, Oscimum sanctum, Santalum album, Phyllanthus Emblica, Convolulus pluricaulis Bacopa monnieri , FM2 ( Lactuca sativa, Juglans regia, Curcuma longa, Vigna mungo, Asphaltum vernacular ), and FM3( Mentha piperita, Juglans regia, Ribes nigrum, Zingiber officinalis, Aloe vera, Cinnamomum zeylanicum, Curcubita pepo, Glycine max, Avena sativa ) on memory acquisition and retention was studied using Elevated plus maze, Morris water maze (MWM) and Pole Climbing apparatus (PCA) in rat. On Application of trancranial media formulations FM1and FM3 showed significant reduction in transfer latency in EPM, MWM and escape latency in PCA test as compared with the control and standard group, whereas FM2 is equally effective in comparison to standard drug but it shown an extremely significant effect compared to control group.