Mucoadhesive microspheres: A review
Keywords:
Mucoadhesive microspheres, Controlled drug delivery, Chitosan, Bioadhesion, Multiparticulate systemsAbstract
Mucoadhesive microspheres are an advanced multiparticulate drug delivery system designed to enhance drug residence time at mucosal surfaces and provide controlled or sustained drug release. By combining the advantages of mucoadhesion and microsphere technology, these systems improve bioavailability, reduce dosing frequency, and enhance patient compliance, particularly for drugs with short half-lives or limited absorption windows. This review discusses the fundamentals of mucoadhesive microspheres, mechanisms of mucoadhesion, polymers used, methods of preparation, evaluation parameters, drug release behavior, applications, challenges, and future perspectives.
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