Buccal films as an emerging drug delivery platform
Keywords:
Buccal films, Mucoadhesion, Polymeric films, Transmucosal delivery, Drug delivery systemsAbstract
Buccal films have emerged as a promising drug delivery platform due to their ability to bypass hepatic first-pass metabolism, improve bioavailability, enhance patient compliance, and provide controlled or rapid drug release. These thin, flexible polymeric films adhere to the buccal mucosa and allow systemic or local delivery of a wide range of therapeutic agents. This review discusses the anatomy and physiology of the buccal mucosa, advantages and challenges of buccal film systems, polymers used for film development, formulation techniques, evaluation parameters, recent advancements, and applications in modern drug delivery. The review concludes that buccal films offer an efficient, patient-friendly, and technologically adaptable platform that will continue to expand in pharmaceutical applications.
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