RP-HPLC force degradation profile of antidiabetic drugs
Keywords:
MET, PIOG, RP-HPLC, Stress,Abstract
A force degradation profile was developed of Metformin (MET) & Pioglitazone (PIOG) in pharmaceutical combine tablet dosage form on RP-HPLCusing Comosil RP-C18 (4.6 x 150mm, 5µm) in an isocratic mode with mobile phase comprising of Acetonitrile: Pott. Dihydrogen Phosphate (pH 2.5 using OPA). The flow rate was 0.7 mL/ min and effluent was monitored at 254.0 nm. The stress conditions selected on the basis of literature review and the drug profile. For both estimations 99.81%for MET and 99.33% for PIOG mean % recovery was found with % RSD was NMT 2.0 which fully agrees by system suitability in good agreement with labeled claimed of formulation. All the parameters of system suitability were fully obeyed during force degradation profile generation.
Downloads
Downloads
Published
Issue
Section
License
Copyright (c) 2015 International Journal of Advances in Scientific Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
