Exploring structure indenture for some Schiff bases as anti-Salmonella typhi drugs: A QSAR Approach

Authors

  • Ameji John Department of Chemistry, Ahmadu Bello University, Zaria, Author
  • Awe Emmanuel Femi Department of Applied Chemistry, Federal University Dutsema, Kastina State Author
  • Adedirin Oluwaseye Chemistry Advance Laboratory, Sheda Science and Technology Complex, FCT, Abuja Author
  • Olusupo Sabitu Department of Chemistry, Kano State University of Science and Technology, Wudil, Kano Author

DOI:

https://doi.org/10.7439/ijasr.v2i2.2765

Abstract

There are many drugs available in the market for treating typhoid infection, but the emergence of multi-drug resistant strain of Salmonella typhi (S. typhi) has necessitated the exploration and development of newer structural moiety of Schiff bases as anti-S. typhi agents owing to their enormous inhibitory activity against this bacterium. In this present study, a Genetic function approximation (GFA) QSAR analysis of some selected Schiff bases with anti-S. typhi activity was performed using OD,1D, 2D and 3D descriptors resulting in the generation of three statistically significant models from which an octa-parametric model was selected as the most robust model

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Published

28-02-2016

Issue

Vol. 2 No. 2 (2016): Feb

Section

Research Articles

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How to Cite

1.
John A, Femi AE, Oluwaseye A, Sabitu O. Exploring structure indenture for some Schiff bases as anti-Salmonella typhi drugs: A QSAR Approach. Int J of Adv in Sci Res [Internet]. 2016 Feb. 28 [cited 2026 Jan. 7];2(2):48-53. Available from: https://ssjournals.co.in/index.php/ijasr/article/view/2765
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