Formulation and Evaluation of Lecithin Organogel for Treatment of Arthritis

Abstract

Arthritis is a disease of the joint that involves inflammation of one or more joints. The common symptoms of arthritis disorders include varied levels of pain, swelling, joint stiffness, and sometimes a constant ache around the joints. More than 20 million individuals with arthritis have severe limitations in function on a daily basis. The objective of this study was to resolve conventional dosage forms of NSAIDs, which are at increased risk for serious gastrointestinal complications, when administered through oral route. Topical administration of NSAIDs could deliver lornoxicam to the site of action in     rheumatic diseases which would reduce the gastrointestinal complications and side effects of the drug. The prepared organogel of lornoxicam were evaluated for its appearance, organoleptic characteristic, viscosity, gelation temperature, drug content and in vitro release study.   In vivo evaluation for analgesic activity of formulation was carried out in terms of skin irritation study, hot plate method, writhing test and edema paw induce method.