Piperazine and Pyrazine containing molecules and their diverse pharmacological activities

Abstract

Efforts were made to synthesize different heterocyclic compounds and their derivatives and were found to posses promising pharmacological compounds. Although piperazine and pyrazine moiety is six membered heterocyclic compounds but is fascinated by scientists because of the diverse biological activities by not only piperazine and pyrazine but its various substituted derivatives as well and having diverse pharmacological activities such antitumor, anticonvulsant, antidepressant, analgesic, antimicrobial, anti?tubercular and anti diabetic, antihistamine, antiinflamatory and other activities. Some compounds also use as flavoring agent in foods. This review is focused on the piperazine and pyrazine derivatives due to its wider applications. They may replace many existing heterocyclic based pharmaceutical compounds. Many drug that containing piperazine and pyrazine moiety while several compounds are in clinical trials.