Anti ulcer activity of leaves of Averrhoa carambola Linn

Authors

  • Ashim Pal Sri Krupa Institute of Pharmaceutical Sciences, Vill: Velkatta, Mdl: Kondapak, Dist: Siddipet. Telangana
  • Santosh Kumar Chinnaiyan Sri Krupa Institute of Pharmaceutical Sciences, Vill: Velkatta, Mdl: Kondapak, Dist: Siddipet. Telangana
  • Arunabha Mallik Marri Laxman Reddy Institute of Pharmacy, Dundigal (V), Hyderabad 500043, Telangana
  • Chiranjib Bhattacharjee Srikrupa Institute of Pharmaceutical Sciences, VilI. Velkatta, Kondapak (mdl), Dist. Medak, Siddipet. Telengana

DOI:

https://doi.org/10.7439/ijpr.v9i5.5209

Keywords:

Averrhoa carambola, Ulcer, histopathology, anti ulcer activity, pylorus ligation, flavonoids

Abstract

Objective: This study screens the aqueous and ethenolic extracts of Averrhoa carambola Linn for antiulcer activity in ethanol induced and pylorus ligated models in rats.

Materials and methods:  The plant material of Averrhoa carambola Linn was extracted by using various solvents like petroleum ether, chloroform, ethanol and water by using soxhlet apparatus. The extracts were screened for antiulcer activity by different in vivo assay methods. Oral acute toxicity study of ethanol extract of Averrhoa carambola (EEAC) and aqueous extract of Averrhoa carambola (AEAC) was done in Wistar albino rats according to OECD guideline. The antiulcer activity of EEAC and AEAC was evaluated in ethanolic and pylorus ligated rats at the doses of 100 & 200 mg/kg body weight. Analysis of biochemical parameters and Histopathological examinations were carried our as per standard protocols.

Results: Acute oral toxicity study indicated that EEAC and AEAC were safe up to a dose of 2000 mg/kg body weight of rats. The results of antiulcer activity study revealed that the extracts of Averrhoa carambola Linn leaves showed significant anti-ulcer activity in dose dependent manner when compared to control. Histopathalogical observations of treated stomach tissues further confirmed the antiulcer efficacy of EEAC& AEAC.

Conclusion: Results indicated possible role of the EEAC and AEAC in the prevention and/or treatment of ulcers. The phenolic / flavonoid contents of EEAC & AEAC having antioxidant potential might be responsible for antiulcer property of Averrhoa carambola leaves.

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Published

2019-06-18

Issue

Vol. 9 No. 5 (2019): May

Section

Research Articles

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How to Cite

1.
Pal A, Chinnaiyan SK, Mallik A, Bhattacharjee C. Anti ulcer activity of leaves of Averrhoa carambola Linn. Int J of Pharmc Res [Internet]. 2019 Jun. 18 [cited 2025 Mar. 14];9(5):e5209. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/5209
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