Acute Oral Toxicity Studies of Ethanol Leaf Extracts Of Derris Scandens & Pulicaria Wightiana In Albino Rats

Authors

  • Vidya Sabbani Department of Pharmacology, VIPER, Narsapur, Medak, Telangana
  • Alluri Ramesh Department of Pharmacology, VIPER, Narsapur, Medak, Telangana
  • Shobharani Satla Department of Pharmaceutical Chemistry, IST, CPS, JNTUH, Hyderabad, Telangana

DOI:

https://doi.org/10.7439/ijpr.v5i1.1579

Abstract

Objective: The present study was designed to find out LD50 and to ascertain the safety of ethanol extracts of leaves of Derris scan dens and Pulicaria wightiana by acute oral toxicity study in female rats as per OECD guideline 425. Methods: Rats were sequentially administered with ethanol leaf extracts of Derris scandens (Ds) and Pulicaria wightiana(Pw) in single dosages of 175, 550, and 2000 mg/kg of body weight. All the animals were individually studied for mortality, wellness parameters and body weight for 14 days. Results: No mortality and no significant changes were observed in body weight and wellness parameters at 175, 550 and 2000 mg/kg body wt. doses of both Derris scandens and Pulicaria wightiana , which reveal the safety of these plants in the doses up to 2000 mg/kg body weight. Conclusion: Conclusively, LD50 value of ethanol extracts of leaves of Derris scandens and Pulicaria wightiana were found to be more than 2000 mg/kg body weight.

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Published

2015-02-06

Issue

Vol. 5 No. 1 (2015): Jan

Section

Research Articles

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How to Cite

1.
Sabbani V, Ramesh A, Satla S. Acute Oral Toxicity Studies of Ethanol Leaf Extracts Of Derris Scandens & Pulicaria Wightiana In Albino Rats. Int J of Pharmc Res [Internet]. 2015 Feb. 6 [cited 2025 Mar. 14];5(1):12-7. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/1579
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