Liposomal delivery of Jamun extract in gel formulation and its evaluation

Abstract

Jamun is a flavorful fruit rich in antioxidant compounds. A fruit possessing Antidiabetic properties. The fruits of Jamun were collected and authenticated, the pulp was dried and extracted with alcohol and distilled water. The extractive values were found using ethanol and distilled water. The pharmacognostic evaluation parameters of Jamun pulp powder were estimated, including extractive values, total ash value, acid-insoluble ash value, water soluble ash value and loss on drying, foaming index, and swelling index. The phytochemical screening of Jamun extract was performed and it was found to contain a variety of phytochemicals, including anthocyanins, vitamins, polyphenols, sugars. The preformulation studies were conducted for the excipients added to the formulation. Liposomes enclosing Jamun extract were formulated. Liposomes were formulated to protect the skin against damaging conditions in the external environment. They have the ability to provide protection for a longer duration of time and providing a clear-cut advantage over traditional dosage forms. The liposomes formulated were added to Carbopol 940 base to form a liposomal gel formulation. The formulation was evaluated for organoleptic properties, pH, spreadability, homogeneity, viscosity, UV analysis, IR Spectrum interpretation, Topographic imaging, percentage release characteristics, and stability studies.