Pharmacognostical and pharmacological evaluation bark of Lavandula stoechas for anti-diabetic potential
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Lavandula stoechasAbstract
In the present study the bark of Lavandula stoechas were evaluated for their toxicity studies and for antidiabetic activity as they have been reported to have antidiabetic activity in the traditional system of medicine.
Different model systems like alloxan, streptozotocinviruses, insulin antibodies, hormones like dexamethasone, adrenaline and dithizone are available to screen the anti-diabetic activity of a given substance. In the present study chemicals like alloxan and streptozotocin were used to produce marked diabetic effects in animals. Alloxan diabetic model resembles type-I diabetes (IDDM) without significant insulin resistance whereas streptozotocin induced diabetic animals inhibit reduced response to insulin in hepatic and peripheral tissues. Further rats treated with streptozotocin display many of the features seen in human with uncontrolled diabetes mellitus.
The literature screened in the process of the proposed work indicates that the bark of Lavandula stoechascontain classes of chemical constituents which have shown antidiabetic activity. Plant taken for proposed work has no scientific claims for antidiabetic activity. Phytochemical and pharmacological investigations of the selected plant may yield useful information and material for better management for preventing diabetes. It can be concluded that the traditional formulation of Lavandula stoechashave a significant antidiabetic potential. However, further work needs to be done for isolating the main constituents responsible for this activity and for elucidating the mechanism of action of the antidiabetic activity of these three plant extracts.
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