The antioxidant and anti-inflammatory activities of Picralima nitida seeds ethanol and hexane extracts
Keywords:
P.nitida, anti-inflammation, antioxidant, paw edema, carrageenan.Abstract
Medicinal plants have been observed to provide cures to certain ailments. Various parts of these plants have been employed ethnomedicinally as remedy for fever, hypertension, jaundice, gastrointestinal disorders, malaria etc. This study evaluated the in vitro antioxidant potential and in vivo anti-inflammatory activity of the hexane and ethanol extracts of Picralima nitida seeds. In vitro antioxidant studies carried out include Ferric-reducing antioxidant power assay and DPPH (1, 1-diphenyl-2picryl-hydrdrazyl) radical scavenging activity. The quantitative phytochemical assessment carried out was the total phenol content. In vivo anti-inflammatory study was performed using carrageenan induced-paw edema model. Hexane extract and ethanol extract of P. nitida seeds possess antioxidant activities whereas ethanol extract possessed higher phenol content than the hexane extract. In vivo studies, showed that hexane extract suppressed carrageenan induced paw edema at the late phases of inflammation (3rd-6th hour) when compared with the standard, Diclofenac sodium. This study suggests that P. nitida possesses antioxidant and anti-inflammatory properties, with these pharmacological activities among others serving as the base for its use in traditional medicine.
Downloads
Downloads
Published
Issue
Section
License
Copyright (c) 2020 International Journal of Phytopharmacy

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).