Anti-diarrhoeal activity of leaves of Averrhoa carambola Linn.
DOI:
https://doi.org/10.7439/ijpp.v9i2.5208Keywords:
Averrhoa carambola, diarrhea, antidiarrhoeal activity, gastrointestinal motility, flavonoidsAbstract
Objective: This study screens the aqueous and ethanolic extracts of Averrhoa carambola Linn for antidiarrhoeal activity in Castor oil induced diarrhea model and Prostaglandin induced diarrhea model, Gastro-intestinal motility test model in mice.
Materials and methods: The plant material of Averrhoa carambola Linn was extracted by using various solvents like petroleum ether, chloroform, ethanol, and water by using soxhlet apparatus. The extracts were screened for antidiarrhoeal activity by different in vivo assay methods. The acute toxicity of Averrhoa carambola Linn was determined in albino mice of either sex weighing from 20 - 25g according to the Organization for Economic Co-operation and Development (OECD) guidelines for Testing of Chemicals number 420 (OECD, 2001). The study was initiated with a sighting study aimed to determine the dose for the acute toxicity study.
Results: Acute oral toxicity study indicated that ethanolic extract of Averrhoa carambola (EEAC) and aqueous extract of Averrhoa carambola (AEAC) was safe up to a dose of 2000 mg/kg body weight of mice. Results of antidiarrhoeal activity study revealed that the extracts of Averrhoa carambola Linn leaves showed significant anti-diarrhoeal activity in a dose-dependent manner when compared to control.
Conclusion: Results indicated a possible role of the EEAC& AEAC in the prevention & treatment of diarrhea. The phenolic/flavonoid contents of EEAC& AEAC having antioxidant potential might be responsible for the antidiarrhoeal property of Averrhoa carambola leaves.
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