Pharmacognostical, Phytochemical Evaluation and in silico lead finding of Ficus bengalensis Linn with hepatoprotective potentials

Authors

  • Ramesh Patel aktu (higia institute of pharmaceutical research and education.
  • Parjanya Kumar Shukla Department of Pharmaceutical Sciences, Faculty of Health Science, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad, India
  • Mahendra Pratap Singh Krishnarpit Institute of Pharmacy, Allahabad, India

DOI:

https://doi.org/10.7439/ijpp.v7i5.4308

Abstract

Present communication deals with the study of Pharmacognostical, phytochemical screening and antihepatotoxic activity prediction of compounds isolated from Ficus bengalensis Linn in order to search lead compound. Dried leaves and bark powder material was used for determination of ash value, extractive value, and phytochemical constituents. Twelve compounds from the whole plant of Ficus bengalensis were subjected to molecular properties prediction and drug-likeness by Lipinski rule of five and Molinspiration software. Phytochemical screening proved the presence of chemical constituent like tannins, alkaloids, proteins, starch, flavanoids, and glycoside. 9 compounds of the plant fulfill the requirements of Drug likeness were taken for biological activity calculation with the help of Molinspiration software and compared with standard drug Silibinin. On comparision of compounds with silibinin, Friedelin, ? - sitosterol, 3,5,7-trimethyl ether of delphinidin-3-O-?-L rhamnoside, 3,5 dimethyl ether of leucocynaidin-3-O-?-D-glactosylcellobioside and 20-tetratriacontene-2-one fullfill Lipinski rule of five and showed good bioactivity score than Silibinin. Out of 12 compounds Friedelin, ?-sitosterol and 5 dimethyl ether of leucocynaidin-3-O-?-D-glactosylcellobioside showed good bioactivity score as compared to Silibinin. So these compound can be considered as lead compounds with hepatoprotective activity from Ficus bengalensis.

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Author Biographies

  • Parjanya Kumar Shukla, Department of Pharmaceutical Sciences, Faculty of Health Science, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad, India
    Research Associate
  • Mahendra Pratap Singh, Krishnarpit Institute of Pharmacy, Allahabad, India
    Associate Professor

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Published

2017-10-28

Issue

Section

Research Articles

How to Cite

1.
Pharmacognostical, Phytochemical Evaluation and in silico lead finding of Ficus bengalensis Linn with hepatoprotective potentials. Int J of Phytopharm [Internet]. 2017 Oct. 28 [cited 2025 Mar. 14];7(5):57-63. Available from: https://ssjournals.co.in/index.php/ijpp/article/view/4308