Preliminary Phytochemical Screening and Scientific Validation of the Anti-Diabetic Effect of the Dried Husk of Zea mays L. (Corn, Poaceae)

Authors

  • Abena Amponsaa Brobbey Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Sandra Somuah-Asante Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Samuel Asare-Nkansah Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Francis Osei Boateng Tree of Life Clinic, Box 9778, Adum-Kumasi, Ghana
  • Isaac Ayensu Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

DOI:

https://doi.org/10.7439/ijpp.v7i1.3925

Abstract

The dried husk of Zea mays L. (Poaceae) also known as corn husk (CH) has been used as traditional remedies in some cultures including Ghana for the management/treatment of Diabetes Mellitus (DM, Type 2). However, there is no evident documentation on the phytoconstituents of CH and the scientific validation of the antidiabetic properties of CH. Therefore, the methanolic and aqueous extracts of CH were phytochemically screened, and the decoction of CH was administered to human subjects (type 2 diabetic patients with uncontrolled blood glucose level). The fasting blood glucose levels of subjects on regularly prescribed oral antidiabetic agents were determined over a period of three weeks. In addition to the regular oral antidiabetic medications, decoctions of CH were administered to the subjects for a further period of three weeks, and the fasting blood glucose levels were again determined. The fasting blood glucose level of the control group was however monitored continuously for a period of six weeks. The phytochemical analyses of the CH extracts revealed the presence of flavonoids, saponins, alkaloids and glycosides as common constituents of the aqueous and methanolic extracts, whereas tannins and phenols were found exclusively in the methanolic extract. The decoction of CH demonstrated a significant anti-diabetic property, attesting to the traditional use of CH as antidiabetic therapy.

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Author Biographies

  • Abena Amponsaa Brobbey, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
    Department of Pharmaceutical chemistry, lecturer
  • Sandra Somuah-Asante, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
    Department of Pharmaceutical chemistry, M.Phil
  • Samuel Asare-Nkansah, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
    Department of Pharmaceutical chemistry, Senior Lecturer
  • Francis Osei Boateng, Tree of Life Clinic, Box 9778, Adum-Kumasi, Ghana
    Tree of Life Clinic, Box 9778, Adum-Kumasi, Ghana

  • Isaac Ayensu, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
    Department of Pharmaceutical chemistry, Senior Lecturer

References

Zhang Y, Wu L, Ma Z, Cheng J, Liu J. Anti-Diabetic, anti-oxidant and anti-hyperlipidemic activities of flavonoids from Corn Silk on STZ-induced diabetic mice. Molecules. 2015; 21(1): 1 - 11.

Van Roozendaal BW, I. Krass I. Development of an evidence-based checklist for the detection of drug related problems in type 2 diabetes. Pharm. World Sci. 2009; 31(5): 580

Aladag I, Eyibilen A, G

Dierckx N., Horvath G, van Gils C, Vertommen J, van de Vliet J, De Leeuw I, Manuel-y-Keenoy B. Oxidative stress status in patients with diabetes mellitus: relationship to diet.. Eur. J. Clin. Nutr. 2003; 5 (8): 999

Goldstein, BJ. Insulin resistance as the core defect in type 2 diabetes mellitus. Am. J. Cardiol. 2002; 90: 3 - 10.

Hong SH, Heo JI, Kim JH, Kwon SO, Yeo KM, Bakowska-Barczak AM, Kolodziejczyk P, Ryu OH, Choi MK, Kang YH, Lim SS, Suh HW, Huh SO, Lee JY. Antidiabetic and beta cell-protection activities of purple corn anthocyanins. Biomol. Ther. 2013; 21(4): 284

Ibrahim MA, Islam MS. Anti-diabetic effects of the acetone fraction of Senna singueana stem bark in a type 2 diabetes rat model. J. Ethnopharmacol. 2014; 153: 392

Kumanyika S, Jeffery RW, Morabia A, Ritenbaugh C, Antipatis VJ. Obesity prevention: the case for action. Int. J. Obes. Relat. Metab. Disord. 2002; 26(3): 425

www.idf.org/membership/afr/ghana

Shafi S, Tabassum N. Survey on anti-diabetic plants in Kashmir [India]. Journal of Advanced Pharmacy Education & Research. 2013; 3(4): 306 - 318.

Venkateshwarlu E, Sharavana Bhava BS, Achyuth Bharadwaj S, Shiva Kumar R,

Umasankar K, Venkateshwar Rao J. Evaluation of diuretic and antidiabetic activities of esculin in wistar rats. Int J Pharm Bio Sci. 2015; 5(2): 267-276.

Huang B, Wang Z, Park JH, Ryu OH, Choi MK, Lee JY, Kang YH, Soon Sung Lim SS. Anti-diabetic effect of purple corn extract on C57BL/KsJ db/db mice. Nutr Res Pract. 2015; 9(1): 22-9.

Thiraphatthanavong P, Wattanathorn J, Muchimapura S, Thukham-mee W, Wannanon P, Tong-un T, Suriharn B, Lertrat K. Preventive effect of Zea mays L. (Purple Waxy Corn) on experimental diabetic cataract. BioMed Res. Int. 2014; 2014: 1-8.

Nile SH, Park SW. Antioxidant, ?-Glucosidase and Xanthine Oxidase inhibitory activity of bioactive compounds from Maize (Zea mays L.). Chem Biol Drug Des. 2014; 83: 119

Kyselova Z, Stefek M, Bauer V. Pharmacological prevention of diabetic cataract. J Diabetes Complications. 2004; 18(2): 129

Guo H, Guo J, Jiang X, Li Z, Ling W. Cyanidin-3-O-b-glucoside, a typical anthocyanin, exhibits antilipolytic effects in 3T3-L1 adipocytes during hyperglycemia: Involvement of FoxO1-mediated transcription of adipose triglyceride lipase. Food Chem Toxicol. 2012; 9: 3040-7.

Milind P, Isha D. Zea mays: A modern craze. Int. Res. J. Pharm. 2013; 4(6): 39-43.

Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and Extraction; A Review. Internationale Pharmaceutica Sciencia. 2011; 1(1): 99-106.

Ram J, Moteriya P, Chanda S. Phytochemical screening and reported biological activities of some medicinal plants of Gujarat region, J Pharmacog Phytochem. 2015; 4(2): 192-198

http://www.diabetes.co.uk/diabetes_care/fasting-blood-sugar-levels

Bhogireddy N, A.Naga vamsi krishna A, Ramesh B, Pradeep kumar M,

Reddy OVS, Gaddaguti V, Raj kumar K, Pola PK, Venkataraman B. Anti-inflammatory and anti-diabetic activities with their other ethnomedicinal properties of the plants. J. Med. Plants Stud. 2013; 1(5): 87 - 96.

Vadlamani S, bala durga Devi KBD, Poosarala A, Bapatla VK. Identification of plant sources from North Andhra Pradesh exhibiting immunomodulatory activity using BALB/c models. Int J Pharm Bio Sci. 2016; 7(1): (B) 295 - 300.

Alam EA. Evaluation of antioxidant and antibacterial activities of Egyptian Maydis stigma (Zea mays hairs) rich in some bioactive constituents. J Am Sci. 2011; 7(4): 726 -8.

Rauter AP, Martins A, Borges C, Mota-Filipe H, Pinto R, Sepodes B, Justino J, Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats. Phytother Res. 2010; 24: S133 -S138

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Published

2017-02-23

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Section

Research Articles

How to Cite

1.
Preliminary Phytochemical Screening and Scientific Validation of the Anti-Diabetic Effect of the Dried Husk of Zea mays L. (Corn, Poaceae). Int J of Phytopharm [Internet]. 2017 Feb. 23 [cited 2025 Mar. 14];7(1):01-5. Available from: https://ssjournals.co.in/index.php/ijpp/article/view/3925