Microencapsulated Garcinia kola and Hunteria umbellata Seeds Aqueous Extracts Part 1: Effect of microencapsulation process

Authors

  • Matthew Arhewoh Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria
  • Okhamafe O. Augustine Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City300001,
  • Auriemma Finizia
  • De Rosa Claudio
  • Di Girolamo Rocco

DOI:

https://doi.org/10.7439/ijpp.v6i1.3028

Keywords:

Keywords, Postpartum hemorrhage, atony, B-Lynch, uterine salvage

Abstract

Objective: This study investigates microcapsulated aqueous extracts of Garcinia kola (GK) and Hunteria umbellata (HU) seeds. Method: Extracts obtained after maceration of dried powdered seeds were prepared as microcapsules with chitosan-alginate by counterion coacervation method. Microcapsules were characterized using differential scanning calorimetry (DSC), x-ray diffractometry (XRD) and fourier transform infrared (FTIR) spectroscopy. In vitro release studies were carried out at pH 1.2 for 2 h and 6.8 for a further 10 h. Results : Between 20 and 50% extract release occurred from microcapsules after 2 h while conventional tablets released 100% after 1 h at simulated gastric pH. At pH 6.8, >80% of extract was released from microcapsules after 6 h. DSC revealed the presence of complex materials. XRD and FTIR showed stable character of the plant extracts within the microcapsules. Conclusion: Controlled release of aqueous extracts derived from these plants was achieved by microencapsulation and therefore can be developed as suitable delivery devices.

Downloads

Download data is not yet available.

Downloads

Published

2015-12-30

Issue

Vol. 6 No. 1 (2016): Jan-Feb

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

How to Cite

1.
Microencapsulated Garcinia kola and Hunteria umbellata Seeds Aqueous Extracts Part 1: Effect of microencapsulation process. Int J of Phytopharm [Internet]. 2015 Dec. 30 [cited 2025 Mar. 14];6(1):01-9. Available from: https://ssjournals.co.in/index.php/ijpp/article/view/3028