Lonicera japonica protects spargue-dawley rat against 11?-HSD1 induced endothelial dysfunction in metabolic syndrome

Authors

  • Chiragkumar Amrutlal Prajapati Research Scholar, Hemchandracharya North Gujarat University Patan, Gujarat,
  • Falguni D Majmudar Assistant Professor, Department of Pharmacology, Smt.NHL.Municipal Medical College, Ahmedabad

DOI:

https://doi.org/10.7439/ijpp.v5i5.2897

Abstract

Objective: To study the pharmacological evaluation of Lonicera japonioca with reference to metabolic syndrome in order to restored 11?-HSD1 induced endothelial dysfunction in SD rats. Introduction : Metabolic syndrome is multidisciplinary metabolic disorder in which Diabetes Mellitus, Hypertension and Obesity are presented jointly. Chlorogenic acid is a major bioactive component in the flower buds of Lonicera japonica having 11?-HSD1 property. 11?-HSD1 induced endothelial dysfunction has been postulated to be a major contributor to the pathogenesis of Metabolic Syndrome. Methods :Present studies were aimed towards investigating the effectiveness of this LJALE extract against STZ-HFD induced diabetes and associated complications, Fructose induced hypertension and HFD induced obesity respectively using SD rats. Parameters like ex vivo 11?-HSD 1 inhibition assay, Vascular reactivity study, Nitric Oxide and Peroxynitrile have been measured. Results: Chlorogenic acid isolated from LJALE could dose dependently inhibit the 11?-HSD1 activity. LJALE attenuate the 11?-HSD1 induced endothelium dysfunction in rats. LJALE treated obese animal reflect significant increased Nitric oxide and decreased Peroxynitrile. Conclusion: From all above statements It has been concluded that Lonicera japonica protects SD rats against 11?-HSD1 induced endothelium dysfunction in Metabolic Syndrome.

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Author Biography

  • Falguni D Majmudar, Assistant Professor, Department of Pharmacology, Smt.NHL.Municipal Medical College, Ahmedabad
    Pharmacology

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Published

2016-01-24

Issue

Vol. 5 No. 5 (2015): Sep-Oct

Section

Research Articles

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How to Cite

1.
Lonicera japonica protects spargue-dawley rat against 11?-HSD1 induced endothelial dysfunction in metabolic syndrome. Int J of Phytopharm [Internet]. 2016 Jan. 24 [cited 2025 Mar. 14];5(5):099-107. Available from: https://ssjournals.co.in/index.php/ijpp/article/view/2897