Antimicrobial activity and brine shrimp toxicity of methanolic whole plant extract of Boerhavia repens L. (Family:Nyctaginaceae)

Authors

  • Syed Masudur Rahman Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814
  • Md. Masud Alam Department of Microbiology, Noakhali Science and Technology University, Sonapur, Noakhali-3814
  • Mohammad Ruhul Amin Department of Microbiology, Noakhali Science and Technology University, Sonapur, Noakhali-3814
  • Fakruddin Md. Institute of Food Science and Technology, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka
  • A F M Shahid- Ud-Daula Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814
  • Rokeya Siddiqui Department of Microbiology, Noakhali Science and Technology University, Sonapur, Noakhali-3814

DOI:

https://doi.org/10.7439/ijpp.v4i6.114

Abstract

This study was designed to explore the phytochemicals, antioxidant, cytotoxic, and antimicrobial activities of the crude methanolic extract of Boerhavia repens L. (Family: Nytaginaceae). The phytochemical screening of the crude extract revealed the presence of alkaloid, carbohydrate, glycoside, phenol, tannin, steroid, flavonoid, protein, saponin, and terpens. For the evaluation of antioxidant activity, total phenolic content was determined which manifests moderate antioxidant property (189.670.5204 mg/g of gallic acid equivalent) of the plant. The cytotoxic property of the crude methanolic extract of Boerhavia repens L. was assessed by using the brine-shrimp lethality bio-assay. The crude methanolic extract showed significant cytotoxic potential (LC50value 4.192 ?g/ml and LC90 value 124.33?g/ml) comparing with vincristine sulphate, a potent cytotoxic agent. The crude methanolic extract of Boerhavia repens L. was screened for antimicrobial activity against a number of Gram positive bacteria, Gram negative bacteria and Fungi using disc diffusion method. The extract showed mild antimicrobial activity against Gram positive bacteria (10mm to 12mm) and moderate antimicrobial activities against Gram negative bacteria and fungi (15mm to 17 mm) at a concentration of 30?g/disc.

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Published

2014-12-30

Issue

Vol. 4 No. 6 (2014): Nov-Dec

Section

Research Articles

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How to Cite

1.
Antimicrobial activity and brine shrimp toxicity of methanolic whole plant extract of Boerhavia repens L. (Family:Nyctaginaceae). Int J of Phytopharm [Internet]. 2014 Dec. 30 [cited 2025 Mar. 14];4(6):135-9. Available from: https://ssjournals.co.in/index.php/ijpp/article/view/1472