In silico approach for alpha-amylase inhibitory activity of diosmetin and galangin

Authors

  • Arumugam Madeswaran Lecturer, Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore-641044, Tamil Nadu, India.
  • Kuppusamy Asokkumar Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, Tamil Nadu, India
  • Muthuswamy Umamaheswari Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, Tamil Nadu, India
  • Thirumalaisamy Sivashanmugam Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, Tamil Nadu, India
  • Varadharajan Subhadradevi Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, Tamil Nadu, India

DOI:

https://doi.org/10.7439/ijpp.v4i5.110

Keywords:

Key words, Teaching aids, multimedia, Audiovisual aids, medical education, PowerPoint, OHP, Blackboard, Lectures.

Abstract

Objective: The objective of the current study is to evaluate the ?-amylase inhibitory activity of diosmetin and galangin using in silico docking studies. Methods: In this perspective, diosmetin and galangin were prepared for the docking evaluation. Acarbose, a known ?-amylase inhibitor was used as the standard. In silico docking studies were carried out using recent version of AutoDock 4.2, which has the basic principle of Lamarckian genetic algorithm. Results: The results showed that the selected flavonoids showed binding energy ranging between -6.84 kcal/mol to -5.96 kcal/mol when compared with that of the standard (-1.97 kcal/mol). Inhibition constant (9.73 M to 42.76 M) and intermolecular energy (-8.33 kcal/mol to -7.15 kcal/mol) of the ligands also coincide with the binding energy. Conclusion: Diosmetin and galangin contributed excellent ?-amylase inhibitory activity than the standard because of its structural parameters. These molecular docking analyses of the selected compounds could lead to the further development to find the potent ?-amylase inhibitors for the treatment of diabetes.

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Author Biography

  • Arumugam Madeswaran, Lecturer, Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore-641044, Tamil Nadu, India.
    Lecturer, Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore-641044, Tamil Nadu, India.

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Published

2014-10-30

Issue

Vol. 4 No. 5 (2014): Sep-Oct

Section

Research Articles

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How to Cite

1.
In silico approach for alpha-amylase inhibitory activity of diosmetin and galangin. Int J of Phytopharm [Internet]. 2014 Oct. 30 [cited 2025 Mar. 14];4(5):124-7. Available from: https://ssjournals.co.in/index.php/ijpp/article/view/1197