Tumor inhibitory activity of methanolic and ethyl acetate soluble extracts of Thuja occidentalis L. on mice bearing Ehrlich ascites carcinoma.

Authors

  • Archana M Navale Asst Professor, Dept of Pharmacology, Parul Institute of Pharmacy P.O. Limda, Ta. Waghodia, Dist.Vadodara-391760. Gujarat, India.
  • Gaurang B Shah Department of pharmacology, K.B. Institute of Pharmaceutical Education and research, Gandhinagar
  • Anand B Pithadia Department of Pharmacology, Parul Institute of Pharmacy, P.O. Limda, Ta. Waghodia, Dist.Vadodara-391760. Gujarat, India.

DOI:

https://doi.org/10.7439/ijpp.v4i3.91

Abstract

Thuja occidentalis (Cupressaceae) is an ornamental plant of European origin. It has been used in folk medicine for the treatment of cancer. Mice bearing Ehrlich Ascites Carcinoma (EAC mice) were treated with methanolic extract (165 mg/kg), ethyl acetate soluble fraction (30 mg/kg) and combination of both extracts of TO. Inhibition of tumor growth, increase in survival time of animal with treatment, and hematological parameters were determined. Both methanolic and ethyl acetate soluble fractions of TO exerted tumor growth inhibitory activity in mice bearing EAC. Combination treatment of two extracts showed more pronounced effect. In conclusion, Methanolic and ethyl acetate soluble extracts of TO exhibit anticancer activity against Ehrlich ascites carcinoma in mice. Thus, it has anticancer potential and should be further evaluated in higher models.

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Published

2014-06-30

Issue

Vol. 4 No. 3 (2014): May-Jun

Section

Research Articles

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How to Cite

1.
Tumor inhibitory activity of methanolic and ethyl acetate soluble extracts of Thuja occidentalis L. on mice bearing Ehrlich ascites carcinoma. Int J of Phytopharm [Internet]. 2014 Jun. 30 [cited 2025 Mar. 14];4(3):86-8. Available from: https://ssjournals.co.in/index.php/ijpp/article/view/1187