Chromatographic development of validated analytical method for the estimation of tapentadol and paracetamol in combined dosage form

Authors

  • Manoj S. Charde Government College of Pharmacy, Kathora Naka, Amrawati-444604 Maharashtra
  • Ashwini A. Patil Government College of Pharmacy, Kathora Naka, Amrawati-444604 Maharashtra
  • Jitendra Kumar Government College of Pharmacy, Kathora Naka, Amrawati-444604 Maharashtra
  • A. S. Welankiwar Government College of Pharmacy, Kathora Naka, Amrawati-444604 Maharashtra
  • R. D Chakole Department of Pharmacy, Government Polytechnic, Amravati - 444603

DOI:

https://doi.org/10.7439/ijpp.v3i6.67

Abstract

A simple, sensitive an isocratic RP-HPLC method for the estimation of TAP (Tapentadol) and PARA (Paracetamol) in combined dosage form using Inertsil ODS C-18 column (250.6 mm, 5 ) in an isocratic mode with mobile phase comprising Buffer (1mL TEA) : ACN : MeOH in the ratio of (75:20:5 v/v/v). The flow rate was 1.2 mL/ min and effluent was monitored at 220 nm. The retention times were found to be 6.88 min for TAP and 3.78 min for PARA. The assay exhibited a linear dynamic range of 11.89- 28.55 g/mL for TAP and 64.95- 155.90 g/mL for PARA.

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Author Biography

  • Manoj S. Charde, Government College of Pharmacy, Kathora Naka, Amrawati-444604 Maharashtra
    Assitant Professor

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Published

2014-01-06

Issue

Vol. 3 No. 6 (2013): Nov- Dec

Section

Research Articles

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How to Cite

1.
Chromatographic development of validated analytical method for the estimation of tapentadol and paracetamol in combined dosage form. Int J of Phytopharm [Internet]. 2014 Jan. 6 [cited 2025 Mar. 14];3(6):90-8. Available from: https://ssjournals.co.in/index.php/ijpp/article/view/1167