Hypoglycemic Effect of Polyalthia longifolia on Glucose Tolerance in Glucose-Induced Hyperglycemic Mice and Analgesic Effect of Polyalthia longifolia in acetic acid-induced writhing model Mice

Authors

  • Md Shamsuddin Sultan Khan The University of Asia Pacific
  • Md. Ahsan Habib Department of Pharmacy, Bangladesh University, Dhaka, Bangladesh
  • Iftekhar Chowdhury Department of Pharmacy, University of Development Alternative, Dhaka, Bangladesh
  • Md Aminul Islam Department of Pharmacy, University of Asia pacific, Dhaka, Bangladesh
  • Debabrata Saha Department of Pharmacy, University of Development Alternative, Dhaka, Bangladesh

DOI:

https://doi.org/10.7439/ijpp.v3i6.62

Abstract

The high level of blood glucose causes the diabetes and many of the diseases are concerned with the symptom of acute or chronic pain. The present study showed the hypoglycemic and analgesic effect of ethanolic extract of Polyalthia Longifolia leaf was investigated. Oral glucose tolerance test was performed in the present study to find the hypoglycemic effect and acetic acid-induced writhing method was used to test the analgesic effect of the leaves. The hypoglycemic effect was found from 16.25 mM to 6.22 mM SEM at the dose of 500 mg extract (p 0.05). The analgesic activity was observed 69.46 % and 58.08% at the rate of 500 mg and 250 mg (p 0.05) respectively compared to writhing inhibition of standard drug Diclofenac 78.16%. The presence of Alkaloid, Flavonoid, Gum, Tannin and Saponin in the extract of leaves may be the reason of these effects. Polyalthia Longifolia has much potential in the medicine of diabetic and pain.

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Author Biography

  • Md Shamsuddin Sultan Khan, The University of Asia Pacific
    Research Associate, SAMUEL MESSINGER (Inventor), BOCA Raton, Florida, USA and Department of Pharmacy, University of Asia Pacific, Dhaka-Bangladesh.

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Published

2013-12-30

Issue

Vol. 3 No. 6 (2013): Nov- Dec

Section

Research Articles

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How to Cite

1.
Hypoglycemic Effect of Polyalthia longifolia on Glucose Tolerance in Glucose-Induced Hyperglycemic Mice and Analgesic Effect of Polyalthia longifolia in acetic acid-induced writhing model Mice. Int J of Phytopharm [Internet]. 2013 Dec. 30 [cited 2025 Mar. 14];3(6):86-9. Available from: https://ssjournals.co.in/index.php/ijpp/article/view/1166