Antipyretic and antimicrobial potential of Sida spinosa linn. aqueous root extract

Authors

  • Basheer Ahmed Mannasaheb
  • Mashood Ahmed Sangreskopp East West college of pharmacy, Department of Pharmacology, RGUHS University, Bangalore
  • Preeti Kulkarni

DOI:

https://doi.org/10.7439/ijpp.v3i2.49

Abstract

Objective: Antipyretic and antimicrobial potential of Sida spinosa Linn. Aqueous root extract was evaluated using aspirin and chloramphenicol as standard drugs. Materials and methods: Roots were collected and extracted with water. The doses of the extract selected were 200 and 400 mg/kg b.w, according to OECD guidelines. Antipyretic potential was evaluated in Brewers yeast induced pyrexia in rats along with Antimicrobial activity by agar well diffusion technique. Results: Aqueous extract demonstrated highly significant (P 0.01) antipyretic activity during various assessment times (1-5 h) when challenged in yeast induced pyrexia test. Maximum attenuation (65.73% at 3h) was observed at 400mg/kg o.p. Antimicrobial activity against S. aureus, B. subtilis, E. coli and S. aeruginosa, was carried out. All microbes were sensitive and activity was concentration dependent. Conclusion: Sida spinosa Linn. root possesses potent antipyretic and antimicrobial activity and has therapeutic potential.

Downloads

Download data is not yet available.

Author Biography

  • Basheer Ahmed Mannasaheb
    department of pharmacology

Downloads

Published

2013-05-06

Issue

Vol. 3 No. 2 (2013): Mar-Apr

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

How to Cite

1.
Antipyretic and antimicrobial potential of Sida spinosa linn. aqueous root extract. Int J of Phytopharm [Internet]. 2013 May 6 [cited 2025 Mar. 14];3(2):50-5. Available from: https://ssjournals.co.in/index.php/ijpp/article/view/1159