Efficacy of intravenous dexmeditomidine versus lidocaine in attenuation of stress response during intubation for laproscopic procedures
DOI:
https://doi.org/10.7439/ijbr.v7i3.2641Keywords:
Myoepithelioma, Parotid, salivary glandAbstract
Introduction: Haemodynamic instability during intubation is a well documented fact. These responses may produce myocardial ischemia or infarction in susceptible cases. Dexmedetomidine is a newly introduced is a highly selective alpha 2 adrenergic agonist which possesses hypnotic, sedative, anxiolytic, sympatholytic, and opiod sparing, analgesic properties without producing significant respiratory depression. This makes it more favorable drug to be used for attenuating pressor response, as it can be used as an adjunct to anaesthesia. Hence, a randomised controlled trial study is undertaken to compare dexmedetomidine to lidocaine as regards its efficacy on attenuation of intubation response. Objectives: To study the comparative efficacy of Dexmeditomidine and Lidocaine in attenuation of stress response as measured by changes in haemodynamic parameters like heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure. Methodology: 70 patients belonging to the American Society of Anaesthesiology (ASA) physical status classification class 1 and 2, of either sex between 20-45 years, scheduled for laproscopic surgeries were enrolled for study. The patients were randomly allocated into 2 groups. Group A included 35 patients receiving 1mcg/kg IV Inj Dexmeditomidine infusion over 10 min before induction. Group B included 35 patients who received plain preservative free Lidocaine 2%, 1.5mg/kg body weight I.V. bolus 1.5 min prior to laryngoscopy. Results: The study revealed that there is significant difference between(p value 0.05) the two groups during laryngoscopy and intubation with respect to heart rate, systolic blood pressure and diastolic blood pressure. The target group showed significantly less heart rate, systolic and diastolic BP compared to control group. we also found the dose requirement of induction agent, Propofol was also less in study group. Conclusion: Dexmeditomidine significantly attenuates stress response to tracheal intubation with improved haemodynamic stability.
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